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Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development.

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Who we are

Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development. We aim to bring information to our customers that is essential to make informed decisions on which compounds to progress in the drug/compound development pipeline, thereby contributing to the development of better medicines and products and to reduce animal testing. We offer services in the following fields:

Genetic Toxicology

We have extensive experience and knowhow in the field of Genetic Toxicology. We often combine our unique ToxTracker assay with a range of extended protocols and additional assays to unravel the underlying mechanism of genotoxicity and predict the outcomes in the regulatory in vitro and in vivo genotoxicity assays.

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Reproductive Toxicology

By combining our expertise in stem cell technologies and reporter systems, we have generated ReproTracker, an in vitro assay that is able to visualise key processes in the early embryonic development. The assay can be applied to assess developmental toxicology in the early phases of drug development.

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Mechanistic Toxicology

All assays that are developed at Toxys are aimed at understanding the mechanism underlying toxicity. We believe that this mechanistic understanding is key to translate the results from in vitro test systems to a relevance for humans. These mechanism-based test systems can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens and in the development of an Integrated Approach to Testing and Assessment (IATA).

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Toxys in 90 seconds

This video gives you a quick insight into what Toxys could do for you.

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Happy Customers

We work together with a growing number of customers from different industries ranging from pharmaceutical companies to chemical and consumer-goods companies and from large size companies to small start-ups. We offer unique in-house screening capabilities combined with the responsiveness and flexibility found only in smaller companies. Please read what some of our customers said about working together:

Peter Boogaard
Shell

"Mechanism-based screening assays like the ToxTracker can make a valuable contribution to the routine safety compliance screening of our products"

Jacky van Gompel

“A succesfull genotoxicity screening strategy is always dependent on the availability of mechanism of action data, as this will provide a link towards risk assessment. The Toxtracker assay is able to provide this relevant information fast and reliable so that the medicinal chemist is able to drive his chemistry plan into the safe zone.”

Diels van den Dobbelsteen
Synthon

"The ToxTracker assay is an excellent tool to evaluate the genotoxic potential of compounds, generating great additional value by dissecting the underlying genotoxic mechanisms, and thereby better assess the relevance of the genotoxic response in a fast and cost-efficient manner.”

Pekka Heikkinen
Orion

"Orion has worked successfully with Toxys on a couple of occasions. We are happy with the open communication which makes planning the experiments and interpreting the results easy and straightforward. The assay is excellent follow-up for our in-house micronucleus test to reveal the mode-of-action and hence validate or in-validate the borderline positive/negative dilemma."

David Kirkland
Kirkland Consultancy

“In regulatory assessment of carcinogenic or germ cell mutagenic risk, it is becoming increasingly important to understand mode of action, and not just rely on weight of negative evidence from in vivo genotoxicity studies to overrule positive in vitro genotoxicity results. To this end, there is increasing demand for integrated mechanism-based assays like ToxTracker as essential components in the development of safe and specific drugs or products.”

Paula van Rossum

ToxTracker – the better genotoxicity assay

This is the first blog in a series to come to share what we are doing at Toxys and to inspire you. Toxys provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases...

Paula van Rossum

ToxTracker, the future for genotoxicity screening of nanoparticles

Many of the traditional genotoxicity test methods [e.g. unscheduled DNA synthesis assay, bacterial reverse mutation (Ames) test, etc.,] for determining the DNA damaging potential of chemical and biological compounds are not suitable for the evaluation of engineered nanomaterials (ENMs), due to a variety of methodological...

Paula van Rossum

Toxys at Eurotox 2016

From 4-7 September the Eurotox 2016 meeting was held in Seville, Spain. Toxys was joined the conference with their new booth and a poster presentation. With over 1100 participants the meeting was well visited, and we had many interactions with old and (potentially) new partners.We...

Paula van Rossum

Grand Opening new facilities Toxys

On the 26th of May Toxys organised a grand opening party. Over 50 people joined, among which were Innovation Quarter, the Leiden Bioscience Park, Biopartner and various entrepreneurs and collaborators.We are very happy with our new location and state-of-the-art equipment and look forwards to expanding...

Giel Hendriks

ToxTracker assay in Gen Magazine

Check out our recent publication about the ToxTracker assay together with Millipore. The publication shows the the power of the ToxTracker reporter assay in combination with the Millipore Guava platform....

Innovation for Health

During the innovation for Health conference Giel Hendriks will give a presentation on our journey in taking over the world.

GTA annual meeting

Please meet us during the GTA annual event. Giel will give a presentation alongside the event.