European patent for ToxTracker granted
6 July 2017 – Leiden, the Netherlands – Toxys is proud to announce that next to the US patent which already was granted, the European patent for ToxTracker, an unique genotoxicity assay, has been granted.
ToxTracker® assay is a state-of-the-art stem cell-based reporter assay that provides mechanistic insights into the genotoxic properties of pharmaceutical compounds and chemicals. ToxTracker is an unique genotoxicity assay that combines multiple biomarkers to get mechanistic insight into the of action of genotoxic compounds. The assay not only includes markers for DNA damage as predictors for the standard genotoxicity assays, but also includes markers for non-genotoxic MOA, including oxidative stress, protein misfolding and general cellular stress. All these types of cellular damage have been associated with increased cancer risk. ToxTracker can contribute to a mechanism-based, animal-free, cancer hazard and risk assessment of chemicals. ToxTracker can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens by revealing genotoxic modes of action and a number of non-genotoxic modes of action, such as oxidative stress and protein damage. Read more