Innovative chemical safety testing services The powerful combination of unique mechanism-based in vitro assays like ToxTracker and our extensive expertise in the field of genotoxicity enables us to provide our sponsors with in depth information on their compounds. Our Services
ToxTracker - an unique genotoxicity assay
for carcinogenicity hazard assessment
Our unique ToxTracker assay discriminates between induction of DNA damage, oxidative stress and protein damage as primary mechanism of toxicity. ToxTracker
ToxTracker Suite The ToxTracker suite contains a unique collection of in vitro genotoxicity assays that can reliably identify genotoxic compounds and can provide detailed insight into their mode-of-action. ToxTracker Suite ReproTracker: novel in vitro developmental toxicity assay ReproTracker is a human induced pluripotent stem cell (hiPSC)-based assay that assesses key events during early embryonic development and identifies teraogens. ReproTracker Screening and in-depth mechanistic genotoxicity testing Our assays can be used as early screening tool as they strongly correlate with the regulatory in vitro and in vivo genotoxicity assays. Alternatively, the assays are frequently used as follow-up for in house testing to validate positive or conflicting test results. Our Services Development of innovative in vitro systems Toxys is always focused on the development of in vitro systems that provide mechanistic understanding of toxicity. We continuously combine our extensive expertise on stem cells and the latest reporter technologies to develop state-of-the-art assays. Our Services

Experts in mechanistic toxicity testing

Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development. We aim to bring information to our customers that is essential to make informed decisions on which compounds to progress in the drug/compound development pipeline, thereby contributing to the development of better medicines and products and to reduce animal testing. We offer services in the following fields:

Genetic Toxicology

We have extensive experience and knowhow in the field of Genetic Toxicology. We often combine our unique ToxTracker assay with a range of extended protocols and additional assays to unravel the underlying mechanism of genotoxicity and predict the outcomes in the regulatory in vitro and in vivo genotoxicity assays.

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Reproductive Toxicology

By combining our expertise in stem cell technologies and reporter systems, we have generated ReproTracker, an in vitro assay that is able to visualise key processes in the early embryonic development. The assay can be applied to assess developmental toxicology in the early phases of drug development.

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Mechanistic Toxicology

All assays that are developed at Toxys are aimed at understanding the mechanism underlying toxicity. We believe that this mechanistic understanding is key to translate the results from in vitro test systems to a relevance for humans. These mechanism-based test systems can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens and in the development of an Integrated Approach to Testing and Assessment (IATA).

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Toxys in 90 seconds

This video gives you a quick insight into what Toxys could do for you.

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Happy Customers

We work together with a growing number of customers from different industries ranging from pharmaceutical companies to chemical and consumer-goods companies and from large size companies to small start-ups. We offer unique in-house screening capabilities combined with the responsiveness and flexibility found only in smaller companies. Please read what some of our customers said about working together:

Maik Schuler - Pfizer
Research Fellow Toxicology

"The differentiation between aneugens and clastogens is important in the hazard assessment of our pharmaceutical compounds. ToxTracker ACE conveniently combines the relevant endpoints to be able to do this"

Damian McHugh - Philip Morris Products
Manager cell & Genetic Toxicology

“As a modern safety laboratory requiring mechanistic insights into mammalian toxicology, we adopted ToxTracker and installed the assay in-house. The expertise, training and support provided by Toxys for the technology transfer were excellent resulting in a seamless set-up of the assay in our facilities. In addition, we have had terrific reactivity from Giel and his team with our questions.”

Diels van den Dobbelsteen - Synthon
Director Nonclinical Safety Evaluation

"The ToxTracker assay is an excellent tool to evaluate the genotoxic potential of compounds, generating great additional value by dissecting the underlying genotoxic mechanisms, and thereby better assess the relevance of the genotoxic response in a fast and cost-efficient manner.”

David Kirkland - Kirkland Consultancy
Consultant

“In regulatory assessment of carcinogenic or germ cell mutagenic risk, it is becoming increasingly important to understand mode of action, and not just rely on weight of negative evidence from in vivo genotoxicity studies to overrule positive in vitro genotoxicity results. To this end, there is increasing demand for integrated mechanism-based assays like ToxTracker as essential components in the development of safe and specific drugs or products.”

Pekka Heikkinen - Orion
Scientist Investigative toxicology

"Orion has worked successfully with Toxys on a couple of occasions. We are happy with the open communication which makes planning the experiments and interpreting the results easy and straightforward. The assay is excellent follow-up for our in-house micronucleus test to reveal the mode-of-action and hence validate or in-validate the borderline positive/negative dilemma."

Jacky van Gompel
Genetic Toxicology

“A succesful genotoxicity screening strategy is always dependent on the availability of mechanism of action data, as this will provide a link towards risk assessment. The Toxtracker assay is able to provide this relevant information fast and reliable so that the medicinal chemist is able to drive his chemistry plan into the safe zone.”

Peter Boogaard - Shell
Global Discipline Leader & Manager Toxicology

"Mechanism-based screening assays like the ToxTracker can make a valuable contribution to the routine safety compliance screening of our products"

Claudia Cusan - S&C BEST Srl
Consultant

“The expertise at Toxys is clear when you discuss results. The proactive team works hard to generate results within the timelines"

Pereni K

Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay

Check out our latest publication “Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay” published recently in Mutation Research/Genetic Toxicology and Environmental Mutagenesis. In this paper published by the International Antimony Association (I2A) in collaboration with Toxys, Boreiko et...

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Toxys strengthens executive team with appointment of a CSO

Leiden, The Netherlands. Feb. 24, 2021 - Today, Toxys announces the appointment of Torben Østerlund as Chief Scientific Officer (CSO). Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative in vitro toxicity screening solutions to identify hazardous properties of compounds...

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Toxys has licensed ToxProfiler technology for animal-free chemical safety testing

Leiden, The Netherlands, January 28, 2021 – Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialize and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals,...

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Toxys is selected as one of the FD Gazelles of 2020!

Toxys is very proud to announce that we have been selected as one of the FD Gazelles of 2020! The prestigious Gazelle awards are presented by the Dutch Financial Times (Het Financieele Dagblad) to fast-growing and financially successful companies in the Netherlands over the last...

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Latest publication about aneugen versus clastogen evaluation and oxidative stress-related MOA

Check out our latest publication "Aneugen versus clastogen evaluation and oxidative stress-related mode-of-action assessment of genotoxic compounds using the ToxTracker reporter assay" published recently in Toxicological Sciences. This paper highlights the extended versions of the ToxTracker assay: ToxTracker ACE and ToxTracker AO. ToxTracker ACE (Aneugen Clastogen...