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Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development.

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Who we are

Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development. We aim to bring information to our customers that is essential to make informed decisions on which compounds to progress in the drug/compound development pipeline, thereby contributing to the development of better medicines and products and to reduce animal testing. We offer services in the following fields:

Genetic Toxicology

We have extensive experience and knowhow in the field of Genetic Toxicology. We often combine our unique ToxTracker assay with a range of extended protocols and additional assays to unravel the underlying mechanism of genotoxicity and predict the outcomes in the regulatory in vitro and in vivo genotoxicity assays.

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Reproductive Toxicology

By combining our expertise in stem cell technologies and reporter systems, we have generated ReproTracker, an in vitro assay that is able to visualise key processes in the early embryonic development. The assay can be applied to assess developmental toxicology in the early phases of drug development.

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Mechanistic Toxicology

All assays that are developed at Toxys are aimed at understanding the mechanism underlying toxicity. We believe that this mechanistic understanding is key to translate the results from in vitro test systems to a relevance for humans. These mechanism-based test systems can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens and in the development of an Integrated Approach to Testing and Assessment (IATA).

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Toxys in 90 seconds

This video gives you a quick insight into what Toxys could do for you.

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Happy Customers

We work together with a growing number of customers from different industries ranging from pharmaceutical companies to chemical and consumer-goods companies and from large size companies to small start-ups. We offer unique in-house screening capabilities combined with the responsiveness and flexibility found only in smaller companies. Please read what some of our customers said about working together:

Peter Boogaard
Shell

"Mechanism-based screening assays like the ToxTracker can make a valuable contribution to the routine safety compliance screening of our products"

Jacky van Gompel

“A succesfull genotoxicity screening strategy is always dependent on the availability of mechanism of action data, as this will provide a link towards risk assessment. The Toxtracker assay is able to provide this relevant information fast and reliable so that the medicinal chemist is able to drive his chemistry plan into the safe zone.”

Diels van den Dobbelsteen
Synthon

"The ToxTracker assay is an excellent tool to evaluate the genotoxic potential of compounds, generating great additional value by dissecting the underlying genotoxic mechanisms, and thereby better assess the relevance of the genotoxic response in a fast and cost-efficient manner.”

Pekka Heikkinen
Orion

"Orion has worked successfully with Toxys on a couple of occasions. We are happy with the open communication which makes planning the experiments and interpreting the results easy and straightforward. The assay is excellent follow-up for our in-house micronucleus test to reveal the mode-of-action and hence validate or in-validate the borderline positive/negative dilemma."

David Kirkland
Kirkland Consultancy

“In regulatory assessment of carcinogenic or germ cell mutagenic risk, it is becoming increasingly important to understand mode of action, and not just rely on weight of negative evidence from in vivo genotoxicity studies to overrule positive in vitro genotoxicity results. To this end, there is increasing demand for integrated mechanism-based assays like ToxTracker as essential components in the development of safe and specific drugs or products.”

Paula van Rossum

First official ToxTracker workshop during SOT 2018

You are cordially invited to join the first official ToxTracker workshop during the SOT 2018 meeting in San Antonio. The workshop provides a unique opportunity to learn more about the ToxTracker reporter assay for cancer hazard assessment. We will update you on the latest developments...

Paula van Rossum

Toxys has been awarded Innovation Credit to further develop ReproTracker

Leiden 20 September 2017 - Today Toxys was awarded an Innovation Credit from RVO to accelerate the develop of the ReproTracker assay. ReproTracker® is a state-of-the-art in vitro reporter assay to rapidly identify compounds that disturb stem cell differentiation and early embryonic development. Testing for...

Paula van Rossum

European patent for ToxTracker granted

6 July 2017 - Leiden, the Netherlands - Toxys is proud to announce that next to the US patent which already was granted, the European patent for ToxTracker, an unique genotoxicity assay, has been granted.About ToxTracker ToxTracker® assay is a state-of-the-art stem cell-based reporter assay that...

Paula van Rossum

Toxys launches large international validation study for ToxTracker

Leiden,  1 May 2017 - Together with a consortium of leading experts in the field of genotoxicity, Toxys has started a large inter-laboratory validation study for their ToxTracker assay. With this study, Toxys aims to demonstrate the transferability, intra- and inter-laboratory reproducibility as well as...

ToxTracker workshop at SOT 2018

You are cordially invited to join the first official ToxTracker workshop during the SOT 2018 meeting in San Antonio. The workshop provides a unique opportunity to learn more about the ToxTracker reporter assay for cancer hazard assessment. We will update you on the latest developments around ToxTracker and its applications. You can learn about experiences from ToxTracker users and ask your questions about how ToxTracker can be valuable for you.Presentations: Giel Hendriks - CEO - Toxys Krista Dobo - Senior director genetic toxicology - Pfizer global R&D Stefan Pfuhler - Global expert genetic toxicology - Procter&Gamble Damian McHugh - Manager genetic toxicology - Philip Morris InternationalWhen: March 13 between 6.00pm and 8.00pm Where: Grand Hyatt San Antonio, Room Republic A-B Register: If you want to join, please register via SOT2018@toxys.com

Snacks and drinks will be provided

  ToxTracker is a unique state-of-the-art stem cell-based reporter assay that provides mechanistic insights into the genotoxic properties of pharmaceutical compounds and chemicals. The assay not only includes markers for DNA damage but also for different non-genotoxic modes of action, including oxidative stress, protein misfolding and cytotoxicity. ToxTracker can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens.

SOT 2018 schedule of events for Toxys

Presentation during the Charles River-sponsored session: “What can in vitro toxicology learn from Genetic Toxicology for regulatory acceptance”. When: March 12, 3.00pm - 4.00pm Where: Convention Center 217DYou can also meet us at our posters:
  • Monday, March 12, 3:00pm - 4:30pm # 1534/P752 Validation of the ToxTracker Reporter Assay for the Genetic Toxicology Assessment of Petroleum Products
  • Monday, March 12, 3:00pm - 4:30pm # 1527/P745 The ToxTracker Reporter Assay Detects Indirect Genotoxicity by High-Levels of Oxidative Stress
  • Monday, March 12, 3:00pm - 4:30pm # 1520/P738 Interlaboratory Validation of the ToxTracker Genotoxicity Reporter Assay
  • Monday, March 12, 3:00pm - 4:30pm # 1524/P742 Genotoxicity Assessment of Antimony Compounds Using the ToxTracker Assay
  • Thursday, March 15, 8:30 AM - 11:30 AM # 3625/ P419 Development of A Stem Cell-based Reporter Assay For In Vitro Dart Assessment
You are welcome at our booth #  1745 If you are interested in learning more about ToxTracker or our services, just visit us at the booth or send an email to p.vanrossum@toxys.com

Society of Toxicology – Annual meeting 2018

ToxTracker workshop:
 You are cordially invited to join the first official ToxTracker workshop during the SOT 2018 meeting in San Antonio. The workshop provides a unique opportunity to learn more about the ToxTracker reporter assay for cancer hazard assessment. We will update you on the latest developments around ToxTracker and its applications. You can learn about experiences from ToxTracker users and ask your questions about how ToxTracker can be valuable for you.Presentations: Giel Hendriks - CEO - Toxys Krista Dobo - Senior director genetic toxicology - Pfizer global R&D Stefan Pfuhler - Global expert genetic toxicology - Procter&Gamble Damian McHugh - Manager genetic toxicology - Philip Morris InternationalWhen: March 13 between 6.00pm and 8.00pm Where: Grand Hyatt San Antonio, Room Republic A-B Register: If you want to join, please register via SOT2018@toxys.comPresentation during the Charles River-sponsored session: “What can in vitro toxicology learn from Genetic Toxicology for regulatory acceptance”.
When: March 12, 3.00pm - 4.00pm
Where: Convention Center 217DYou can also meet us at our posters: • Monday, March 12, 3:00pm - 4:30pm # 1534/P752 Validation of the ToxTracker Reporter Assay for the Genetic Toxicology Assessment of Petroleum Products • Monday, March 12, 3:00pm - 4:30pm # 1527/P745 The ToxTracker Reporter Assay Detects Indirect Genotoxicity by High-Levels of Oxidative Stress • Monday, March 12, 3:00pm - 4:30pm # 1520/P738 Interlaboratory Validation of the ToxTracker Genotoxicity Reporter Assay • Monday, March 12, 3:00pm - 4:30pm # 1524/P742 Genotoxicity Assessment of Antimony Compounds Using the ToxTracker Assay • Thursday, March 15, 8:30 AM - 11:30 AM # 3625/ P419 Development of A Stem Cell-based Reporter Assay For In Vitro Dart AssessmentYou are welcome at our booth # 1745

Eurotox 2018

We will join the Eurotox 2018 meeting. More information on our booth and posters will follow soon.