for carcinogenicity hazard assessment
Experts in mechanistic toxicity testing
Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development. We aim to bring information to our customers that is essential to make informed decisions on which compounds to progress in the drug/compound development pipeline, thereby contributing to the development of better medicines and products and to reduce animal testing. We offer services in the following fields:
We have extensive experience and knowhow in the field of Genetic Toxicology. We often combine our unique ToxTracker assay with a range of extended protocols and additional assays to unravel the underlying mechanism of genotoxicity and predict the outcomes in the regulatory in vitro and in vivo genotoxicity assays.
By combining our expertise in stem cell technologies and reporter systems, we have generated ReproTracker, an in vitro assay that is able to visualise key processes in the early embryonic development. The assay can be applied to assess developmental toxicology in the early phases of drug development.
All assays that are developed at Toxys are aimed at understanding the mechanism underlying toxicity. We believe that this mechanistic understanding is key to translate the results from in vitro test systems to a relevance for humans. These mechanism-based test systems can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens and in the development of an Integrated Approach to Testing and Assessment (IATA).
We work together with a growing number of customers from different industries ranging from pharmaceutical companies to chemical and consumer-goods companies and from large size companies to small start-ups. We offer unique in-house screening capabilities combined with the responsiveness and flexibility found only in smaller companies. Please read what some of our customers said about working together:
“Generating human relevant developmental toxicity data at an early phase of drug development is crucial for safely progressing anti-malaria compounds to the clinic for pregnant women and WCBP who are the most affected by the disease after children. The ReproTracker assay is an ideal tool for this, and the team at Toxys has been instrumental for the interpretation of the data and to helps us develop a “anti-malaria compound library”. Amer’s willingness and scientific input was key to help solved some of the challenges that we face working with marketed compounds. The camaraderie developed between MMV and Toxys was crucial when we wrote scientific papers and presented data at international meetings.”
“ToxTracker brings added value to the genotox testing strategy in the fragrances sector. Being able to distinguish between direct and indirect genotoxicity has instrumentally improved genotoxicity predictions and facilitates moving away from animal testing”.
"The ToxTracker team helped us understand the mixed results we encountered in our standard in vitro genotoxicity assays. The mode-of-action information has proved to be very valuable in obtaining regulatory approval for progressing our compound into the clinic".
"The differentiation between aneugens and clastogens is important in the hazard assessment of our pharmaceutical compounds. ToxTracker ACE conveniently combines the relevant endpoints to be able to do this".
“We are very happy to work with Toxys to develop and implement ReproTracker for exposure-led in vitro developmental toxicity testing. Toxys have stood out as a developer and provider of data from innovative NAMs that underpin human-focused bioactivity point-of-departure determinations without pathology in animals. We experience a great synergy from our combined efforts to raise the bar in non-animal based next generation safety assessments”.
“In regulatory assessment of carcinogenic or germ cell mutagenic risk, it is becoming increasingly important to understand mode of action, and not just rely on weight of negative evidence from in vivo genotoxicity studies to overrule positive in vitro genotoxicity results. To this end, there is increasing demand for integrated mechanism-based assays like ToxTracker as essential components in the development of safe and specific drugs or products.”
"In our company we are striving to move away from animal testing as much as possible. While obtaining relevant mechanistic information for chemical safety assessment, the ToxTracker and ToxProfiler assays developed by Toxys also provide for an important contribution to the support of read-across approaches in regulatory submissions, and ultimately help in the reduction of animal testing".
“As a modern safety laboratory requiring mechanistic insights into mammalian toxicology, we adopted ToxTracker and installed the assay in-house. The expertise, training and support provided by Toxys for the technology transfer were excellent resulting in a seamless set-up of the assay in our facilities. In addition, we have had terrific reactivity from Giel and his team with our questions.”
“A succesful genotoxicity screening strategy is always dependent on the availability of mechanism of action data, as this will provide a link towards risk assessment. The Toxtracker assay is able to provide this relevant information fast and reliable so that the medicinal chemist is able to drive his chemistry plan into the safe zone.”
“The expertise at Toxys is clear when you discuss results. The proactive team works hard to generate results within the timelines"
“Innospec is a global specialty chemicals company focused on bringing novel and disruptive technologies to the markets we serve. As a company we are committed to replacing animal testing with suitable alternatives while ensuring that we can continue to innovate, develop and maintain new and safe products. To uphold these commitments we collaborate with excellent service providers like Toxys to generate data using modern state-of-art and scientifically robust safety testing. The ToxTracker and ToxProfiler assays have been very helpful in assessing the safety profile of numerous products from our portfolio which adds mode-of-action information that we can use to make biologically relevant decisions and enhance alternative approaches like read-across under regulations like EU REACH”.