Toxys is part of organising committee for workshop: Mode of Action Approaches That Identify Genotoxic Mechanisms in Mammalian Cell Systems (May 10th 2017)
The HESI Genetic Toxicology Technical Committee (GTTC) will hold the workshop in conjunction with the Genetic Toxicology Association (GTA) annual meeting on 10 May 2017 in Newark, Delaware. The first part of the workshop is intended to establish key cellular and genetic events for defined molecular initiating events like tubulin poisons, alkylating agents and topoisomerase inhibitors. Similar to adverse outcome pathways (AOPs), the sequence of events will be summarized in a pathway map and possible ways to detect key cellular events will be proposed and discussed.
The second part of the workshop aims to discuss technologies like toxicogenomics, flow cytometric biomarker assays and other mechanistic platforms that could help to establish a genotoxic mode of action. For each of these technologies, the basic platforms will be described and specific examples of each application will be shown. In addition, technologies will be evaluated for favorable and unfavorable properties using a SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis. The outcome of the workshop will be presented on the 2nd day of the GTA meeting.