ACT 44th Annual Meeting

ACT 44th Annual Meeting

The Annual Meeting is the heart of ACT. This November gathering brings together a community of toxicologists at small venues conducive to idea exchange, professional networking, and continuing education. We invite you to our Talking Tox program on the integration of New Approach Methods (NAMs) in Developmental and Reproductive Toxicology.

Talking Tox: Integration of New Approach Methods in Developmental and Reproductive Toxicology
Time: 12:00 – 12:55 PM
Venue: Room Gatlin E2
Lunch is included!

Testing for developmental toxicity according to the current guidelines requires large numbers of animals, making these tests very resource-intensive, time-consuming and ethically debatable. The recent ICH S5 (R3) guideline on developmental and reproductive toxicology proposes the use of alternative assays as part of an integrated testing strategy to minimize the use of animals.

We developed ReproTracker, a NAM to assess developmental toxicity. ReproTracker is a human induced pluripotent stem cell (hiPSC)-based biomarker assay that mimics the early stages of embryonic development. The assay is based on the differentiation of hiPSCs into three germ layer-specific cell types, hepatocytes, cardiomyocytes, and neural rosettes. During this Talking Tox, we will show how ReproTracker was validated according to the ICH S5 (R3) guidelines. We will share some case studies and applications that show the added value of the assay in a developmental toxicity testing strategy.

Please click here to register.

Toxys will also be present with a booth (#232) and several poster presentations on our novel assays:

13 November, 5.00 – 6.30 PM
#412: Determining the Genotoxic Mode of Action of N-Nitrosamines Using DNA Repair-Deficient Cell Lines
#123: Evaluation of the extended ToxProfiler MAX assay for mitochondrial and mechanistic toxicity assessment


Event location: Rosen Shingle Creek Hotel,
9939 Universal Blvd, Orlando,
FL 32819, United States

Meet us at ACT 44th Annual Meeting

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