Join us at the SOT’s 61st Annual Meeting and ToxExpo, a hybrid online and offline meeting that will feature world-class toxicology alongside networking and social opportunities.

Toxys will be present on site with a booth (#1324) and we will also be hosting an Exhibitor sponsored session entitled: OECD Validation of the ToxTracker Assay for Genotoxic Mode of Action Assessment.

Session Description:

ToxTracker is a cell-based reporter assay to assess the mode-of-action of genotoxic compounds. In a large international inter-laboratory validation, the accuracy to predict genotoxicity, intra- and inter-laboratory reproducibility was determined. During this session, we will share the first results and conclusions of this OECD validation. Various partners involved in the project will share their experiences. Finally, we will share some of the improvements that were made to the assay and the learnings for regulatory applications.

Programme:

• Overview OECD validation study

• Experiences from validation partners

• Challenges and learnings

• Applications of ToxTracker

• Conclusions and closing remarks

Presenters:

• Giel Hendriks, Toxys

• Stefan Pfuhler, Procter & Gamble

• Raja Settivari, Corteva Agriscience

• Darren Kidd, Labcorp

You can also meet us at our poster presentations:

29 March, 2.30 – 4.15 PM ET: ReproTracker: a human stem cell-based biomarker assay for in vitro assessment of developmental toxicity #P202

30 March, 9.00 – 10.45 AM ET: Validation of the ToxProfiler reporter assay for toxicological mode-of-action profiling #P119

Find out more about our assays in the posters/sessions by others:

28 March, 2.30 – 4.15 PM ET: An integrated approach for testing Developmental and Reproductive Toxicity (DART) endpoints for Next-Generation Risk Assessment (NGRA) (By Unilever) #P351

29 March, 10.45 AM – 12.30 PM ET: In vitro toxicology assessment of ZYN, oral tobacco-derived nicotine pouches (By Swedish Match) #P571

30 March, 8.00 – 10.45 AM ET: Advancing in vitro genetic toxicity testing through the application of computational workflows using new approach methodologies and in vitro to in vivo extrapolation (Symposium session)

30 March, 9.00 – 10.45 AM ET: The use of ToxTracker for the toxicological assessment of tobacco and nicotine delivery products (By BAT) #P167

30 March, 9.00 – 10.45 AM ET: An experimental analytical, behavioral and in vitro approach for bridging from a foundational dataset to a new tobacco product variant (By BAT) #P201

30 March, 10.45 AM – 12.30 PM ET: The ToxTracker ACE to determine the mode of action of drugs (By Charles River Laboratories Montreal ULC) #P853

30 March, 2.30 – 4.15 PM ET: Chemical analysis and in vitro toxicological evaluation of aerosols from heated tobacco products compared with cigarette smoke tobacco products  (By Japan Tobacco) #P651