Exhibitor Hosted Session
Toxys will present case-studies of NAMs for genetic, developmental and investigative toxicology and how they are used in regulatory or screening setting.
NAMs and Their (Regulatory) Applications in Safety Testing
Tuesday 18 Nov, 12:00-12:55
Room: Grand Sonoran H
Program:
- Update about the development of an OECD Test Guideline for ToxTracker
- Validation of MutaTracker, a novel approach method for the detection of gene mutations using error-corrected NGS
- Case study: Application of ToxProfiler for toxicological profiling and read-across of conazoles
- Case study: Application of ReproTracker for developmental toxicity assessment of PROTACs and molecular glues.
- Update on Charles River Laboratories and Toxys collaboration – presented by Kristina York, Director of Operations and Head of Nevada DART Program at Charles River Laboratories
Resource Download Packages
After filling in the form, you will receive the resource links into your inbox. Just tick boxes of your interest.
Resources in ACT Annual Meeting 2025 packages are as below.
Genetic Toxicology Package
- Poster: Investigating limit dose and identifying genotoxic hazard of common pharmaceutical solvents with ToxTracker
- Flyer: 1) ToxTracker Suite 2) MutaTracker 3) About Toxys
- Publication: 1) Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment 2) Critical Evaluation of Methods for the Identification of Aneugens 3) The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding
- Webinar: Validation of ToxTracker for Regulatory Genetox Testing Strategies
- Case study: Can ToxTracker replace the in vitro micronucleus test?
- Other: Press release – ToxTracker® Approved by OECD for Incorporation into Test Guideline Programme
Download this package.
Or download all 3 packages.
Developmental Toxicology Package
- Poster: In vitro developmental toxicity testing of PROteolysis-TArgeting Chimeras (PROTACs)
- Flyer: 1) ReproTracker 2) About Toxys
- Publication: 1) A novel human stem cell-based biomarker assay for in vitro assessment of developmental toxicity 2) Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment
- Webinar: Application of ReproTracker in assessing developmental toxicity according to ICH S5
- Case study: 1) Biology matters! Early teratogenicity assessments using ReproTracker 2) NAMs to the rescue: developmental toxicity of PROTACs
Download this package.
Or download all 3 packages.
Investigative Toxicology Package
- Poster: 1) Clustering-based analysis of cellular stress responses to elucidate toxicological modes of action of chemicals
- Flyer: 1) ToxProfiler 2) ToxProfiler MAX 3) About Toxys
- Publication: ToxProfiler: A novel human-based reporter assay for in vitro chemical safety assessment
- Case study: Can ToxProfiler guide DILI predictions?
Download this package.
Or download all 3 packages.
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Presentations
In vitro developmental toxicity testing of PROteolysis-TArgeting Chimeras (PROTACs)
Poster P506 | Category: Toxicology Methods | Monday, November 17, 5:00 pm – 6:30 pm
Paula van Rossum (CBO at Toxys)
Investigating limit dose and identifying genotoxic hazard of common pharmaceutical solvents with ToxTracker
Poster P420 | Category: Safety Evaluation Pharmaceuticals | Monday, November 17, 5:00 pm – 6:30 pm
Elias Halkes-Wellstead (Director BD & Sales at Toxys)
Clustering-based analysis of cellular stress responses to elucidate toxicological modes of action of chemicals
Poster P505 | Category: Toxicology Methods | Monday, November 17, 5:00 pm – 6:30 pm
Giel Hendriks (CEO at Toxys)
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Team on Location
Paula van Rossum
CBO
Giel Hendriks
CEO
Elias Halkes-Wellstead
Director BD & Sales
Would you like to have a 1-1 meeting?
Reserve a time slot here.
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