Collaboration with Health Canada and University of Swansea to implement quantitative analysis of ToxTracker results for human risk assessment

Toxys has started a collaboration with Health Canada and the University of Swansea to implement the Quantitative Analysis tool PROAST for ToxTracker results. There is growing interest in quantitative analysis of in vitro genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Utilization of quantitative information, will improve the assessment of risks posed by exposure to genotoxic agents. In this study quantitative assessment for ToxTracker data for hundreds of reference compounds is evaluated, based on the historical data and controls that have been generated for the various biomarker responses in the ToxTracker assay. This project will lead to novel approaches for quantitative analysis of ToxTracker data that can be useful for genotoxicity risk assessment of novel compounds.

Furthermore, we aim to add the Quantitative Analysis and dose response modelling tools to our Toxplot software that is currently used for the analysis of ToxTracker results.

Please contact us via info@toxys.com if you have any questions on this collaboration.