Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay

Check out our latest publication “Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay” published recently in Mutation Research/Genetic Toxicology and Environmental Mutagenesis.

In this paper published by the International Antimony Association (I2A) in collaboration with Toxys, Boreiko et al. tested antimony (Sb) and eleven antimony-containing compounds in the ToxTracker assay to better understand the mode-of-action (MOA). Five pentavalent (Sb(V)) and six trivalent (Sb(III) compounds were included.

None of the compounds activated the DNA damage reporters. Antimony, all Sb(V) and 2 Sb(III) compounds activated the oxidative stress response. The unfolded protein response was activated by antimony and most Sb(III) compounds, but not by Sb(V) compounds. The consistent activation of the oxidative stress reporters suggests this MOA may underlie genotoxicity responses and its compounds.

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