A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods
Check out this latest publication by Proctor & Gamble, “A comparison of classical and 21st century genotoxicity tools: A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods (TGx-DDI, whole genome clustering and connectivity mapping)” published recently in Environmental and Molecular Mutagenesis.
In this proof of concept study, Allemang et al. evaluated two in vitro genotoxicity assays (ToxTracker and the micronucleus assay) and three genomics‐based methods approaches using microarray data for their ability to separate direct acting from indirect acting genotoxicants.
This difference in mode-of-action (MoA) between direct and indirect acting genotoxicants has important implications for the application of the current risk assessment paradigm. In the study 18 compounds, genotoxic and non‐genotoxic chemicals with different MoAs, were included . ToxTracker performed very well in the study in particular in combination with the micronucleus assay.
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