Moving Developmental Toxicology Toward Mechanism-Based Testing
Moving Developmental Toxicology Toward Mechanism-Based Testing 1. The Traditional Model: Effective but Limited Developmental toxicity testing has long relied on traditional testing methods, largely based on standardized animal studies. Commonly, pregnant rats or rabbits are exposed to a substance, and outcomes such as fetal malformations, growth retardation,...
New Book Chapter: Genetic Toxicology Testing in Comprehensive Toxicology
[vc_row][vc_column width="1/6"][vc_single_image image="15845" img_size="full"][/vc_column][vc_column width="5/6"][vc_column_text]Present day genetic toxicity testing looks different than it did 20 years ago. The chapter dedicated to this topic in Comprehensive Toxicology has been revised with a focus on genotoxic mechanisms. In addition to identifying mutagenicity, aneugenicity, and clastogenicity, new approach...
New publication: Trilineage differentiation in ReproTracker for accurate teratogenicity assessment
Toxys scientists recently published an article in Frontiers in Toxicology entitled “Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment”. This publication not only describes the optimization of ReproTracker to include assessment of neurodevelopmental toxicants and in a higher throughput manner, but...
NAMs for Assessing Developmental Toxicity of Pharmaceuticals: Moving the Needle Forward
Scientist from various prestigious organizations, including Toxys CSO Amer Jamalpoor, recently published “New approach methodologies for assessing developmental toxicity of pharmaceuticals: Case examples and future directions” in Reproductive Toxicology. Below, we share highlights from this publication, which can be accessed here. This manuscript is part of...
New Publication: Cellular uptake and genotoxic potential of industrial relevant nanomaterials in vitro
Evaluating the potential genotoxicity of nanomaterials (NMs) presents a unique challenge when using cell-based models. In addition to the requirement for physicochemical characterization of the test article, a negative genotoxicity test result is only trusted if the material has access to internal cellular components (evidence...
A tiered approach to developmental and reproductive toxicology with NAMs
[vc_row][vc_column][vc_column_text]Unilever and Toxys scientists recently published an article in Frontiers in Toxicology entitled “An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox”. The DART NAM toolbox and NGRA framework As outlined in Next Generation Risk Assessment (NGRA) frameworks,...
New Publication: Critical Evaluation of Methods for the Identification of Aneugens
[vc_row][vc_column][vc_column_text]As a member of HESI’s Genetic Toxicology Testing Committee (GTTC), we co-published an article in Environmental and Molecular Mutagenesis entitled “Critical Evaluation of Methods for the Identification of Aneugens”. This article presents the strengths, weaknesses, opportunities, and threats for a variety of technologies currently being...
New publication: Genotoxicity testing of N-nitrosamines using mammalian cells
[vc_row][vc_column][vc_column_text]Toxys scientists recently published an article in Environmental and Molecular Mutagenesis entitled “An Enhanced Metabolization Protocol for In Vitro Genotoxicity Assessment of N-Nitrosamines in Mammalian Cells”. In this article, we established a proof of concept for an exogenous metabolization protocol that activates N-nitrosamines (NAs) and...
Advancing Chemical Safety Testing Through NAMs!
[vc_row][vc_column][vc_column_text]We recently published an article entitled “Toxicological mode-of-action and developmental toxicity of different carbon chain length PFAS” in Toxicology Letters together with Honeywell. We utilized two of our advanced assays, ToxProfiler and ReproTracker, to assess the toxicological mode-of-action and developmental toxicity of different PFAS with varying...
New publication: In vitro safety assessment of 100 chemicals with ToxProfiler
[vc_row][vc_column][vc_column_text]Toxys scientists recently published an article in Toxicology entitled “ToxProfiler: A novel human-based reporter assay for in vitro chemical safety assessment”. In this article, ToxProfiler is presented as a robust platform that not only provides accurate toxicity profiles of chemicals but also reveals their toxicological mode-of-action (MoA)....
