Integration and application of new approach methodologies in assessing the developmental hazards: Case study with an antimalarial drug
Check out this publication in which ReproTracker was utilized by Medicines for Malaria Venture (MMV) to verify the teratogenicity potential of an antimalarial agent and address the interspecies differences. Their study demonstrated that the use of NAMs, such as ReproTracker, can be helpful in understanding the...
Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose
Check out this recent publication by the Genetic Toxicology Technical Committee (GTTC) on in vitro to in vivo extrapolation (IVIVE) for genotoxicity. In vitro genotoxicity assays, including ToxTracker, were able to reliably predict in vivo genotoxicity from animal studies. Please click here to read the full...
Chemical and in vitro toxicological comparison of emissions from a heated tobacco product and the 1R6F reference cigarette
It has previously been found that, compared with cigarette smoke, the aerosols generated by heated tobacco products contain fewer and lower harmful and potentially harmful constituents (HPHCs) and elicit lower biological activity in in vitro models and lower smoking-related exposure biomarker levels in clinical studies. Here,...
Utility of ToxTracker in animal alternative testing strategy for fragrance materials
Check out this new paper by RIFM, P&G, and Toxys on how ToxTracker can be applied for testing fragrance materials. In an evaluation combining different genotoxicity assays, ToxTracker was a valuable tool for identifying the genotoxic potential of fragrances along with the mechanisms of action....
Quantitative interpretation of ToxTracker dose-response data for potency comparisons and mode-of-action determination
Check out our latest publication about quantitative dose-response modeling for ToxTracker to improve the predictions for in vivo genotoxicity. We used the BMD approach to assess the mode-of-action of genotoxic compounds. This information can be highly valuable for regulatory applications. Please click here for the paper....
Cytotoxicity Mechanisms of Eight Major Herbicide Active Ingredients in Comparison to Their Commercial Formulations
Most research on plant protection products focuses on active ingredients, while co-formulants are generally considered non-toxic. To investigate the actual toxicity of these commercial formulations, S. Ferguson and colleagues at Kings College London researched 8 major herbicides using ToxTracker and several other assays. Click here to...
Exploring the molecular and functional cellular response to hydrazine via transcriptomics and DNA repair mutant cell lines
Here is an interesting case study of our new DNA Repair-Profiler assay. AbbVie applied our panel of DNA repair-deficient cell lines to explore the genotoxicity of hydrazine. Hydrazine is a rodent carcinogen and is classified as a probable human carcinogen by IARC. Though hydrazine is...
Search for the optimal genotoxicity assay for routine testing of chemicals: Sensitivity and specificity of conventional and new test systems
In the recent publication by Mišík et al. about New Approach Methods (NAMs) for genotoxicity testing, ToxTracker was highlighted as one of the NAMs. These NAMs are advantageous in that they provide insight into the mode-of-action of genotoxic substances. The authors concluded that promising alternatives to in vivo experiments could...
Testing the RangerPro herbicide with the ToxTracker assay for a mechanistic insight into the toxicity
In a recent publication by Mesnage et al, all the pesticide ingredients in the US glyphosate-based herbicides(GBHs) RangerPro were tested for toxicity. The ToxTracker assay identified the toxicity resulting from RangerPro exposure as multifactorial, involving ER stress caused by a polyoxyethylene tallow amine, POE-15, along with oxidative stress caused by glyphosate. Please click here to read the full...
TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity
Check out our latest publication entitled "TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity" on the TubulinTracker assay, which studies the microtubule cytoskeleton dynamics in living cells. TubulinTracker belongs to the ToxTracker suite and can measure...
