Publications

An in vitro assay being performed.
Pereni K

Search for the optimal genotoxicity assay for routine testing of chemicals: Sensitivity and specificity of conventional and new test systems

In the recent publication by Mišík et al. about New Approach Methods (NAMs) for genotoxicity testing, ToxTracker was highlighted as one of the NAMs. These NAMs are advantageous in that they provide insight into the mode-of-action of genotoxic substances. The authors concluded that promising alternatives to in vivo experiments could...

An image showing a modern farmer to represent the agrochemical industry
Pereni K

Testing the RangerPro herbicide with the ToxTracker assay for a mechanistic insight into the toxicity

In a recent publication by Mesnage et al, all the pesticide ingredients in the US glyphosate-based herbicides(GBHs) RangerPro were tested for toxicity. The ToxTracker assay identified the toxicity resulting from RangerPro exposure as multifactorial, involving ER stress caused by a polyoxyethylene tallow amine, POE-15, along with oxidative stress caused by glyphosate. Please click here to read the full...

Pereni K

TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity

Check out our latest publication entitled "TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity" on the TubulinTracker assay, which studies the microtubule cytoskeleton dynamics in living cells. TubulinTracker belongs to the ToxTracker suite and can measure...

Pereni K

Empirical comparison of genotoxic potency estimations: the in vitro ToxTracker versus the in vivo micronucleus assay

Check out this latest publication, “Empirical comparison of genotoxic potency estimations: the in vitro DNA-damage ToxTracker endpoints versus the in vivo micronucleus assay” published recently in Mutagenesis. In this comparative study, John Wills, Paul Rees, George Johnson and colleagues (Cambridge and Swansea Universities) used a benchmark dose (BMD)...