Quantitative interpretation of ToxTracker dose-response data for potency comparisons and mode-of-action determination
Check out our latest publication about quantitative dose-response modeling for ToxTracker to improve the predictions for in vivo genotoxicity. We used the BMD approach to assess the mode-of-action of genotoxic compounds. This information can be highly valuable for regulatory applications. Please click here for the paper....
Cytotoxicity Mechanisms of Eight Major Herbicide Active Ingredients in Comparison to Their Commercial Formulations
Most research on plant protection products focuses on active ingredients, while co-formulants are generally considered non-toxic. To investigate the actual toxicity of these commercial formulations, S. Ferguson and colleagues at Kings College London researched 8 major herbicides using ToxTracker and several other assays. Click here to...
Exploring the molecular and functional cellular response to hydrazine via transcriptomics and DNA repair mutant cell lines
Here is an interesting case study of our new DNA Repair-Profiler assay. AbbVie applied our panel of DNA repair-deficient cell lines to explore the genotoxicity of hydrazine. Hydrazine is a rodent carcinogen and is classified as a probable human carcinogen by IARC. Though hydrazine is...
Search for the optimal genotoxicity assay for routine testing of chemicals: Sensitivity and specificity of conventional and new test systems
In the recent publication by Mišík et al. about New Approach Methods (NAMs) for genotoxicity testing, ToxTracker was highlighted as one of the NAMs. These NAMs are advantageous in that they provide insight into the mode-of-action of genotoxic substances. The authors concluded that promising alternatives to in vivo experiments could...
Testing the RangerPro herbicide with the ToxTracker assay for a mechanistic insight into the toxicity
In a recent publication by Mesnage et al, all the pesticide ingredients in the US glyphosate-based herbicides(GBHs) RangerPro were tested for toxicity. The ToxTracker assay identified the toxicity resulting from RangerPro exposure as multifactorial, involving ER stress caused by a polyoxyethylene tallow amine, POE-15, along with oxidative stress caused by glyphosate. Please click here to read the full...
TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity
Check out our latest publication entitled "TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity" on the TubulinTracker assay, which studies the microtubule cytoskeleton dynamics in living cells. TubulinTracker belongs to the ToxTracker suite and can measure...
Genotoxicity evaluation of 2,4-D, dicamba & glyphosate alone or in combination with cell reporter assays
Check out this latest publication, “Genotoxicity evaluation of 2,4-D, dicamba and glyphosate alone or in combination with cell reporter assays for DNA damage, oxidative stress and unfolded protein response” published recently in Food and Chemical Toxicology. Researchers at Kings College in London have evaluated the carcinogenic...
Empirical comparison of genotoxic potency estimations: the in vitro ToxTracker versus the in vivo micronucleus assay
Check out this latest publication, “Empirical comparison of genotoxic potency estimations: the in vitro DNA-damage ToxTracker endpoints versus the in vivo micronucleus assay” published recently in Mutagenesis. In this comparative study, John Wills, Paul Rees, George Johnson and colleagues (Cambridge and Swansea Universities) used a benchmark dose (BMD)...
A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods
Check out this latest publication by Proctor & Gamble, “A comparison of classical and 21st century genotoxicity tools: A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods (TGx-DDI, whole genome clustering and connectivity mapping)” published recently in Environmental...
Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay
Check out our latest publication “Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay” published recently in Mutation Research/Genetic Toxicology and Environmental Mutagenesis. In this paper published by the International Antimony Association (I2A) in collaboration with Toxys, Boreiko et...