Empirical comparison of genotoxic potency estimations: the in vitro ToxTracker versus the in vivo micronucleus assay
Check out this latest publication, “Empirical comparison of genotoxic potency estimations: the in vitro DNA-damage ToxTracker endpoints versus the in vivo micronucleus assay” published recently in Mutagenesis. In this comparative study, John Wills, Paul Rees, George Johnson and colleagues (Cambridge and Swansea Universities) used a benchmark dose (BMD)...
A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods
Check out this latest publication by Proctor & Gamble, “A comparison of classical and 21st century genotoxicity tools: A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods (TGx-DDI, whole genome clustering and connectivity mapping)” published recently in Environmental...
Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay
Check out our latest publication “Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay” published recently in Mutation Research/Genetic Toxicology and Environmental Mutagenesis. In this paper published by the International Antimony Association (I2A) in collaboration with Toxys, Boreiko et...
Latest publication about aneugen versus clastogen evaluation and oxidative stress-related MOA
Check out our latest publication "Aneugen versus clastogen evaluation and oxidative stress-related mode-of-action assessment of genotoxic compounds using the ToxTracker reporter assay" published recently in Toxicological Sciences. This paper highlights the extended versions of the ToxTracker assay: ToxTracker ACE and ToxTracker AO. ToxTracker ACE (Aneugen Clastogen...
ToxTracker applied for testing Cobalt nanoparticles
In collaboration with scientists at the Karolinska institute and KTH in Sweden, we recently published a paper about application of ToxTracker for genotoxicity testing of Cobalt nanoparticles. There is a growing demand for fast and reliable assays to identify nanoparticle-induced toxicity and underlying mechanisms. In the...
Poster together with Concawe presented at the SOT 2017: Use of ToxTracker for Petrochemical products
The goal of this project was to investigate whether the ToxTracker assay can be applied to petroleum UVCBs as a high-content screen for mutagenicity / carcinogenicity by testing by testing twelve DMSO extracts of petroleum substances for (geno)toxic properties in the assay. Conclusions: The ToxTracker assay...
Poster together with P&G presented at the SOT 2017: use of multiparametric mode of action approaches for genetic toxicity assessment
This poster describes the investigation of several different predictive, animal-free genetic toxicology methodologies with varying degrees of complexity. The predictive capacity of these methods was compared by testing 22 chemicals that represent a mix of DNA reactive chemicals, chemicals with known, mixed or unknown modes...
ToxTracker, the future for genotoxicity screening of nanoparticles
Many of the traditional genotoxicity test methods [e.g. unscheduled DNA synthesis assay, bacterial reverse mutation (Ames) test, etc.,] for determining the DNA damaging potential of chemical and biological compounds are not suitable for the evaluation of engineered nanomaterials (ENMs), due to a variety of methodological...
Application note Millipore featuring the ToxTracker assay
Benchtop flow cytometry facilitates discrimintion between induction of DNA damage, oxidative stress and protein misfolding using a novel multicell GFP reporter assay. ...
ToxTracker suggested as part of “An integrative test strategy for cancer hazard”
A recent publication by the Dutch National Institute for Health and Environment (RIVM) reviews the current test methods for cancer hazard identification that have been adopted by the regulatory authorities and discusses the most promising alternative methods that have been developed to date. Based on...