July Newsletter 2021

Toxys Newsletter July 2021
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Toxys expands in new laboratories to meet global demand for animal free safety assessment
The Toxys team has settled into new laboratories and offices at the brand new BioPartner 5 building in the Leiden Bio Science Park. The BioPartner 5 building is constructed from recycled materials and uses natural, eco-friendly materials to provide a sustainable and inspiring working environment. The building is the first energy-neutral Paris-Proof laboratory building in the Netherlands!

This unique building has allowed Toxys to expand its modern laboratory facilities. With the new facilities, we are ready for further growth to meet the global demand for our animal-free laboratory tests for the safety assessment of novel medicines, chemicals, cosmetics and food ingredients. In this new building, we have the space we need to accelerate the development of New Approach Methods (NAMs) to reduce animal testing.
We are excited to be one of the first tenants moving into this sustainable and inspiring workplace!
Applications of NAMs in Genotoxicity and Developmental toxicity testing Session at 11th World Congress on Alternatives and Animal Use

To emphasize our commitment to developing advanced in vitro methods that allow moving away from animal testing, Toxys is participating in the 11th World Congress on Alternatives and Animal Use. During this international conference, on Friday the 27th of August, we will host the session: Applications of New Approach Methods in Genotoxicity and Developmental toxicity testing with speakers from Unilever, Health Canada and Toxys. 

In this session, we will present the latest developments and applications of our ToxTracker and ReproTracker assays for genotoxicity and developmental toxicity assessment. We will discuss how results from the in vitro assays can be extrapolated to in vivo exposures and how these assays help in replacing or reducing animal testing by providing reliable in vitro data. 

Toxys and Unilever join forces to further validate and expand the ReproTracker developmental toxicity assay
Our ReproTracker assay is a hiPSC-based in vitro biomarker assay to identify teratogenic compounds. The assay monitors the differentiation of pluripotent stem cells into functional heart, liver and neural cell lineages. We have extensively validated the assay using reference compound libraries showing high predictivity for the detection of in vivo teratogenic compounds. Consequently, ReproTracker allows a much more rapid and cost-effective developmental toxicity hazard identification for novel and existing drugs, chemicals, and many other substances.

In collaboration with Unilever, we will further develop ReproTracker in order to design a teratogenicity strategy in line with the next generation risk assessment (NGRA) framework that integrates new approach methodologies (NAMs) to ensure product safety without generating animal data. 

Read more in this press release
News in short

Experts recommend ToxTracker in different industries 

In the latest revision of the SCCS "Notes of guidance for testing of cosmetic ingredients", ToxTracker was highlighted in the toolbox of in vitro assays. The mechanistic insight provided by ToxTracker into the genotoxicity of chemicals is useful as an animal-free assessment and in a Weight-of-Evidence (WOE) evaluation. 

ToxTracker is featured in a Special Issue of the “Nanomaterials” book series called "From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials”. Here, ToxTracker is highlighted as a valuable technology for high-throughput rapid screening of genotoxic properties of nanoparticles. 

Recent poster presentations
We have recently made all the Toxys posters available through our website to share the latest developments of our technologies. Here, you can find the posters in the fields of genotoxicity, developmental toxicity and mechanistic toxicity that are presented at various conferences and annual meetings. These posters discuss the use of our in vitro assays across many industries, such as pharmaceutical, agrochemical, metals, etc.

Get in contact

Due to COVID-19, meetings in person have become difficult. We are very happy to instead schedule a call or TC's to tell you more about our technologies and services and to hear about your approach and needs in in vitro toxicology. You can also find us at the following meetings:
11th World Congress on Alternatives and Animal Use in the Life Sciences 22 – 27 August 2021
- EUROTOX Congress, 27 September – 1 October
- EMGS Virtual Annual Meeting, 22 25 October 
- ACT Annual Meeting, Washington, DC, 14 – 17 November

Please take note of our new address:
Leiden Bio Science Park
De Limes 7, 2342 DH 
Oegstgeest, The Netherlands

Please contact us if there are any questions: 

Paula van Rossum                          Hanna Frykman                          Ruairi Mac Siomoin
CBO                                                Director BD & Sales                    Japan liaison (Eaolas Biosciences)
p.vanrossum@toxys.com                h.frykman@toxys.com                macsiomoin@eolas-bio.co.jp   
+31 - 71 - 3322475                          +31 - 71 - 3322475                      +81-47-308-2204

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