Newsletter May 2018

Toxys Newsletter May 2018
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Quantitative analysis of ToxTracker results for human risk assessment

Toxys has started a collaboration with Health Canada and the University of Swansea to implement the Quantitative Analysis tool PROAST for ToxTracker results. There is growing interest in quantitative analysis of in vitro genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Utilization of quantitative information, will improve the assessment of risks posed by exposure to genotoxic agents. In this study quantitative assessment for ToxTracker data for hundreds of reference compounds is evaluated, based on the historical data and controls that have been generated for the various biomarker responses in the ToxTracker assay. This project will lead to novel approaches for quantitative analysis of ToxTracker data that can be useful for genotoxicity risk assessment of novel compounds. 

Furthermore, we aim to add the Quantitative Analysis and dose response modelling tools to our Toxplot software that is currently used for the analysis of ToxTracker results.

ToxTracker Xpress service launched

We recently launched our novel ToxTracker Xpress service to meet the demand for rapid genotoxicity testing solutions. In this service we will fast-track ToxTracker analysis for your compounds. Under this service you will receive a full ToxTracker report within 3 working days! Compounds will be tested in a wide dose range in three independent biological repeat experiments.

Key features:

  • Full genotoxicity profiling in 3 days
  • Extensive mechanistic understanding
  • Excellent predictor for regulatory in vitro and in vivo assays
  • Low amount of compound required

Read more on the ToxTracker Xpress service

New publication: ToxTracker applied for testing Cobalt nanoparticles

In collaboration with scientists at the Karolinska institute and KTH  in Sweden, we recently published a paper about application of ToxTracker for genotoxicity testing of Cobalt nanoparticles. There is a growing demand for fast and reliable assays to identify nanoparticle-induced toxicity and underlying mechanisms. In the paper we show that ToxTracker can be used for rapid (geno)toxicity screening and potency ranking of nanoparticles. The mechanistic toxicity data that are provided by ToxTracker can also be useful for read across approaches. You can read the paper here.

News in short
First ToxTracker workshop at the SOT
At the SOT 2018 in San Antonio we hosted our first ToxTracker workshop, approximately 65 people joined. The workshop provided an unique opportunity to learn more about the ToxTracker reporter assay and included presentations by ToxTracker users from various industries. Please click here to read more on the workshop presentations and other activities at the SOT. 

Blog: ToxTracker and its applications for read-across
Mechanistic toxicity data generated by ToxTracker can be used to justify read-across under REACH. While in silico is the current golden standard, ToxTracker data can be an useful addition to QSAR analyses. The main advantage of ToxTracker for read-across is that the assay provides an extensive toxicity profile of compounds – including genotoxic and non-genotoxic endpoints. See example and read more
Opportunities to get in contact
We will attend and give presentations at several conferences this year. We are more than happy to meet alongside any of these meetings. If you are interested to learn more about our unique assays we could also schedule a TC to tell you more about our technologies and services.

Meetings we will attend: 
- IGG 4 June 2018
- UKEMS 2-5 September 2018
- Eurotox 2-5 September 2018 
- EMGS 22-26 September 2018

Please contact me if there are any questions: 
Paula van Rossum 
Director Business Development & Sales
+31 - 71 - 3322470

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