Pharma targeting

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Toxys is a Dutch biotech company specialised in developing toxicological in vitro assays focussed on understanding the mode-of-action of compounds. These assays are offered both as a service or as a kit/license for in-house use. 

ToxTracker - unique genotoxicity assay
Toxys developed the ToxTracker® assay, our state-of-the-art stem cell-based reporter assay for in vitro cancer hazard assessment. The assay provides mechanistic insights into the genotoxic properties of pharmaceutical compounds. ToxTracker includes markers for DNA damage as predictors for genotoxicity and also includes markers for non-genotoxic MoA, including oxidative stress, protein misfolding and general cellular stress. The assay can be particularly useful for Adverse Outcome Pathway (AOP) and is frequently used as as an early mechanistic screening tool or mechanistic follow-up assay and read across approaches.

ToxTracker ACE - separate Aneugens from Clastogens
ToxTracker ACE (Aneugen Clastogen Evaluation) is an extended version of the ToxTracker assay that can directly discriminate between an aneugenic and a clastogenic mode-of-action. ToxTracker ACE includes extended cell cycle analyses and detection of polyploidy in addition to the ToxTracker reporters. This unique combination gives unparalleled mechanistic insight from a single assay into the hazardous properties of pharmaceuticals. ToxTracker ACE is particularly useful in genotoxicity testing of kinase inhibitors and other aneugens. 

Our unique assays can be easily combined with standard genetox assays such as the comet assay or micronucleus assay in the same cell line! 
 

Read more on our website


Extensively validated
ToxTracker has been extensively validated using various libraries of reference chemicals as well as proprietary compounds and demonstrated a very high sensitivity and specificity (> 90%) for the detection of in vivo genotoxins. The assay is currently under review by ECVAM and OECD. An international ring trial with 8 labs is ongoing. Please see our publications for more information on the assay and some examples of projects we worked on.

Questions or meet-up?
We would welcome the opportunity to meet and share information about ToxTracker and ToxTracker ACE and learn more about your strategy in genetic toxicology. We could easily schedule a TC or meet alongside any of the toxicology meetings such as GTTC/GTA, EMGS, Eurotox. 

Please contact me if you have any questions. 
Best regards, 

Paula van Rossum 
Director BD & Sales 
p.vanrossum@toxys.com
+31-71 3322470

Our assays and Services

How to Access?

Do you want to send compounds out for testing?

1) Services directly via Toxys 
2) Services ordered via scientist.com
3) Access ToxTracker (ACE) via Charles River Laboratories 

 

Do you want to test your compounds In-house?

1) Order the kits
2) License the ToxTracker (ACE) technology
 
Copyright © 2019, All rights reserved.

Our mailing address is:
info@toxys.com

Please visit our website for more information on our products and services and our privacy policy:
www.toxys.com

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