First Results ToxTracker OECD Validation Study to be presented at GTTC-GTA Workshop next week
This year the Genetic Toxicology Technical Committee (GTTC) at HESI will organise a workshop alongside the annual meeting of the Genetic Toxicology Association. The GTTC workshop will be on "Validation of New Approaches in Genetic Toxicology'. During this workshop, several novel in vitro and in vivo genotoxicity assays that are currently undergoing formal OECD validation will be discussed. The workshop will address questions about why was an assay validated, what is assay validated for, what is the positioning for a novel method and what was used as reference for validation. ToxTracker is one of the assays which will be discussed and the first results from the OECD validation study will be presented during the workshop.
To qualify for regulatory use of ToxTracker, the assay is currently subject of an international validation trial designed according to OECD Guidance Document 34. At the workshop we will present in detail how this study was designed and share the first results from this study.
Workshop: Validation of New Approaches in Genetic Toxicology The HESI Genetic Toxicology Technical Committee & the Genetic Toxicology Association When: May 8th between 1.00 pm and 6.00 pm Where: John M. Clayton Hall Conference Center University of Delaware, Newark, DE, USA For more information click here.
Young Scientist Poster Award for ToxTracker ACE
We are very proud that our scientist Inger Brandsma won the UKEMS Young Scientist Poster Award for her poster ‘Extension of the ToxTracker reporter assay for classification of compounds with a clastogenic or aneugenic mode of action’ at BTS-UKEMS Congress 2019. ToxTracker ACE (Aneugen Clastogen Evaluation) is an extended version of the ToxTracker assay and includes direct discrimination between an aneugenic and a clastogenic mode-of-action of genotoxic compounds. ToxTracker ACE combines the power of 6 fluorescent reporter cell lines for detection of DNA damage, oxidative stress and protein damage with cell cycle analyses and detection of polyploidy.
Unilever presented poster on ToxTracker results at BTS-UKEMS
At the recent BTS-UKEMS meeting the Safety & Environmental assurance centre from Unilever presented a poster on the evaluation of ToxTracker for DNA damage and pro-oxidative MoA for 10 coded compounds. The overall conclusion was that ToxTracker enabled them to distinguish between a direct and indirect DNA damaging agents. You can request the poster here.
Opportunities to get in contact
We will attend and give presentations at several conferences this year. We are more than happy to meet alongside any of these meetings. If you are interested to learn more about our unique assays we could also schedule a TC to tell you more about our technologies and services.
Meetings we will attend - GTTC & GTA 5-10 May 2019 - EEMGS 19-23 May 2019 - Eurotox 8-11 September 2019 - EMGS 19-23 September 2019 - ACT 17-20 November 2019