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Webinar: Potency ranking of PFAS using the ToxProfiler assay
On the 28th of November, we hosted a webinar entitled "Potency ranking of PFAS using the ToxProfiler assay". In this webinar, we shared a case study on the comparative analysis of different carbon chain length PFAS using ToxProfiler. Please click here to request the webinar from...
Animal-free assessment of developmental toxicity: Combining PBPK modeling with the ReproTracker assay
Along with Scitovation, we published a paper entitled, "Animal-free assessment of developmental toxicity: Combining PBPK modeling with the ReproTracker assay". This pilot study demonstrated the importance of integrating PBPK model in assessing developmental toxicity in vitro and showed that the combination of these tools can...
Webinar: Integration of ReproTracker and PBPK modeling to predict human developmental toxicity
On the 11th of October, we hosted a webinar entitled "Integration of ReproTracker and PBPK modeling to predict human developmental toxicity". During this webinar, we discussed how PBPK modeling can be applied to perform quantitative in vitro to in vivo extrapolation (IVIVE) of dosimetry and...
Webinar: Validation of ToxTracker for Regulatory Genetox Testing Strategies
On the 19th of September, we hosted a webinar entitled "Validation of ToxTracker for Regulatory Genetox Testing Strategies". During this webinar, we discussed the use of ToxTracker in genetic toxicology testing strategy and also presented findings of the inter-laboratory validation study approved by the OECD. Please...
Webinar: Applications of ToxProfiler for mechanistic toxicity profiling
On the 27th of June, we hosted a webinar entitled "Applications of ToxProfiler for mechanistic toxicity profiling". During this webinar, we introduces an exciting new extension of this assay, ToxProfiler MAX, and shared some case studies on ToxProfiler. Please click here to request the webinar from...
Join us at our ToxTracker hands-on training workshop!
[vc_row][vc_column][vc_column_text] Dates: 12 - 13 October 2023 Venue: Toxys B.V., De Limes 7, Oegstgeest, The Netherlands 2342 DH Join us for a hands-on training workshop on ToxTracker! ToxTracker is a unique genotoxicity assay that can reliably identify genotoxic compounds and can provide detailed insight into their mode-of-action. During the...
Integration and application of new approach methodologies in assessing the developmental hazards: Case study with an antimalarial drug
Check out this publication in which ReproTracker was utilized by Medicines for Malaria Venture (MMV) to verify the teratogenicity potential of an antimalarial agent and address the interspecies differences. Their study demonstrated that the use of NAMs, such as ReproTracker, can be helpful in understanding the...
Webinar: Application of ReproTracker in assessing developmental toxicity according to ICH S5
On the 12th of June, we hosted a webinar entitled "Application of ReproTracker in assessing developmental toxicity according to ICH S5". During this webinar, we showcased how ReproTracker fits in as an alternative assay under ICH S5 (R3) guidelines and highlight a few cases that...
Webinar: ToxTracker: Better Product Risk Assessment Results
Recently, Labstat International Inc. hosted a webinar on how the ToxTracker® genotoxicity assay can streamline nicotine product development. You can learn about how ToxTracker compares to other current tests and case studies from the nicotine industry by accessing the recording of the webinar here. About ToxTracker ToxTracker...
Labstat Inc., a Certified Group Company, partners with Toxys to offer the ToxTracker® assay
[vc_row][vc_column][vc_column_text] TORONTO, March 15, 2023 – Labstat Inc., A Certified Group Company, has entered into a partnership with Toxys to offer the ToxTracker assay at its Kitchener, Ontario laboratory. ToxTracker is a state-of-the-art stem cell-based reporter assay that provides mechanistic insights into the mode of action...
IIVS and Toxys enter into agreement to offer ToxTracker® for in vitro genetic toxicity evaluation
[vc_row][vc_column][vc_column_text] IIVS will offer ToxTracker®, expanding its portfolio of animal-free genetic toxicology assays Gaithersburg, M.D., USA, and Oegstgeest, The Netherlands, March 9, 2023 – The Institute for In Vitro Sciences (IIVS) and Toxys have entered into a license agreement that allows IIVS to offer the ToxTracker® assay....
Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose
Check out this recent publication by the Genetic Toxicology Technical Committee (GTTC) on in vitro to in vivo extrapolation (IVIVE) for genotoxicity. In vitro genotoxicity assays, including ToxTracker, were able to reliably predict in vivo genotoxicity from animal studies. Please click here to read the full...
Chemical and in vitro toxicological comparison of emissions from a heated tobacco product and the 1R6F reference cigarette
It has previously been found that, compared with cigarette smoke, the aerosols generated by heated tobacco products contain fewer and lower harmful and potentially harmful constituents (HPHCs) and elicit lower biological activity in in vitro models and lower smoking-related exposure biomarker levels in clinical studies. Here,...
Utility of ToxTracker in animal alternative testing strategy for fragrance materials
Check out this new paper by RIFM, P&G, and Toxys on how ToxTracker can be applied for testing fragrance materials. In an evaluation combining different genotoxicity assays, ToxTracker was a valuable tool for identifying the genotoxic potential of fragrances along with the mechanisms of action....
Webinar: DNA Repair-Profiler, a new in vitro assay for DNA repair & genotoxic mode of action assessment
On the 31st of January, we hosted a webinar entitled "DNA Repair-Profiler, a new in vitro assay for DNA repair and genotoxic mode of action assessment". During this webinar, we introduced the latest assay to be added to our portfolio: DNA Repair-Profiler. Please click here to request...
Quantitative interpretation of ToxTracker dose-response data for potency comparisons and mode-of-action determination
Check out our latest publication about quantitative dose-response modeling for ToxTracker to improve the predictions for in vivo genotoxicity. We used the BMD approach to assess the mode-of-action of genotoxic compounds. This information can be highly valuable for regulatory applications. Please click here for the paper....
Cytotoxicity Mechanisms of Eight Major Herbicide Active Ingredients in Comparison to Their Commercial Formulations
Most research on plant protection products focuses on active ingredients, while co-formulants are generally considered non-toxic. To investigate the actual toxicity of these commercial formulations, S. Ferguson and colleagues at Kings College London researched 8 major herbicides using ToxTracker and several other assays. Click here to...
The ReproTracker team wins the EPAA Science Prize 2022!
We are very proud that Dr Amer Jamalpoor, study director of ReproTracker and lead scientist in developmental toxicology, was awarded the EPAA European Partnership for Alternatives Science Prize 2022 for outstanding contributions towards animal-alternative testing methods. The awarded case study, “ReproTracker: an animal-free platform for developmental...
Toxys is scaling up in the US
After establishing a Toxys subsidiary in the US last year, we are scaling up our business at Toxys Inc. We have hired a Director of BD & Sales to expand our commercial activities and officially started the production of our ToxTracker kits and reagents in...
Our very first hands-on ToxTracker training!
Last week, we hosted our very first hands-on ToxTracker training together with ALTERTOX on the novel in vitro methods and AOP approaches in genetic toxicology. During the workshop, the participants received a hands-on experience with ToxTracker and learnt about the latest developments in genetic toxicology. We are thankful...
Exploring the molecular and functional cellular response to hydrazine via transcriptomics and DNA repair mutant cell lines
Here is an interesting case study of our new DNA Repair-Profiler assay. AbbVie applied our panel of DNA repair-deficient cell lines to explore the genotoxicity of hydrazine. Hydrazine is a rodent carcinogen and is classified as a probable human carcinogen by IARC. Though hydrazine is...
Search for the optimal genotoxicity assay for routine testing of chemicals: Sensitivity and specificity of conventional and new test systems
In the recent publication by Mišík et al. about New Approach Methods (NAMs) for genotoxicity testing, ToxTracker was highlighted as one of the NAMs. These NAMs are advantageous in that they provide insight into the mode-of-action of genotoxic substances. The authors concluded that promising alternatives to in vivo experiments could...
Testing the RangerPro herbicide with the ToxTracker assay for a mechanistic insight into the toxicity
In a recent publication by Mesnage et al, all the pesticide ingredients in the US glyphosate-based herbicides(GBHs) RangerPro were tested for toxicity. The ToxTracker assay identified the toxicity resulting from RangerPro exposure as multifactorial, involving ER stress caused by a polyoxyethylene tallow amine, POE-15, along with oxidative stress caused by glyphosate. Please click here to read the full...
Now offering DNA Repair-Profiler, the latest addition to our genetic toxicology assays
As of today, Toxys offers DNA Repair-Profiler, the latest addition to our genetic toxicology assays. DNA Repair-Profiler consists of a unique collection of mammalian cell lines, each with a deficiency in one of the major DNA repair pathways. The cell lines are applied to assess...
Webinar: Novel safety assessment of antiviral nucleoside analogues using ToxTracker
On the 30th of June, we hosted a webinar entitled "Novel safety assessment of antiviral nucleoside analogues using ToxTracker". During this webinar we shared the background, details and conclusions for the nucleoside analogues ToxTracker case study. Please click here to request the webinar from us. About ToxTracker ToxTracker...
Toxys is interviewed by Dutch news channel about the importance of animal-testing alternatives
April 24th commemorated the World Day for Animals in Laboratories. Our CEO, Giel Hendriks, was interviewed by RTL Nieuws (Dutch national news channel) to discuss the importance of animal-testing alternatives. At Toxys, we are focused on developing assays that provide a better understanding of toxicity without...
ReproTracker Webinar: ReproTracker as an in vitro alternative to animal models for developmental toxicity testing
On the 10th of March, we hosted a webinar on ReproTracker as an in vitro alternative to animal models for developmental toxicity testing. During the webinar, the technical validation of the ReproTracker assay and the case studies with applications of the assay were presented. Please click...
Toxys opens US office and production facility to accelerate growth
Oegstgeest, The Netherlands. March 16, 2022 - Toxys BV, a Dutch biotech company that offers a broad spectrum of innovative in vitro toxicology solutions for the safety assessment of novel medicines, (agro)chemicals, cosmetics, and food ingredients, today announces the opening of a sales office in...
TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity
Check out our latest publication entitled "TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity" on the TubulinTracker assay, which studies the microtubule cytoskeleton dynamics in living cells. TubulinTracker belongs to the ToxTracker suite and can measure...
ToxTracker is now available at Labcorp
We are very excited that the ToxTracker reporter assay for mechanistic genotoxicity testing is now available as a service from Labcorp. Labcorp is a global CRO that is valued for its scientific expertise and excellence in the field of genotoxicity as well as a deep...
Toxys is a part of Fraunhofer ITEM led consortium in an EMA-funded research project
Toxys is excited to be a part of the consortium led by Fraunhofer ITEM that will shed light on the mutagenicity of different classes of N-Nitrosamines. This joint research project funded by the European Medicines Agency (EMA) will develop in vitro test systems, aiming to...
Toxys is featured in the local newspaper
Searching for toxic substances with fluorescent cells | The course of the Bio Science Park Toxys was featured by Leidsch Dagblad, a local newspaper, in a series which delves into the world of biotech and innovations at the Leiden Bio Science Park. Our steady growth as a company and our commitment to providing human relevant...
Toxys appoints Scientific Advisory Board
Oegstgeest, The Netherlands. November 30, 2021 - Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative, high-fidelity in vitro toxicity screening solutions to identify carcinogenic and other hazardous properties of compounds for the pharmaceutical, chemical, cosmetics and food industry. Today,...
Genotoxicity evaluation of 2,4-D, dicamba & glyphosate alone or in combination with cell reporter assays
Check out this latest publication, “Genotoxicity evaluation of 2,4-D, dicamba and glyphosate alone or in combination with cell reporter assays for DNA damage, oxidative stress and unfolded protein response” published recently in Food and Chemical Toxicology. Researchers at Kings College in London have evaluated the carcinogenic...
ToxProfiler Webinar: Validation & applications of the ToxProfiler assay for mechanistic toxicity profiling
On the 14th of October, we hosted a webinar on the validation and applications of ToxProfiler, a quantitative high throughput screening platform with a single-cell resolution. The webinar is now available through the link below. During the webinar, our guest speaker, Dr. Romain Grall, also shared...
Toxys Newsletter September 2021
Here you can view our newsletter from September 2021 [campaign id="523f0fa92b"]...
Empirical comparison of genotoxic potency estimations: the in vitro ToxTracker versus the in vivo micronucleus assay
Check out this latest publication, “Empirical comparison of genotoxic potency estimations: the in vitro DNA-damage ToxTracker endpoints versus the in vivo micronucleus assay” published recently in Mutagenesis. In this comparative study, John Wills, Paul Rees, George Johnson and colleagues (Cambridge and Swansea Universities) used a benchmark dose (BMD)...
Toxys hosts a session at the 11th World Congress on Alternatives and Animal Use in the Life Sciences
Toxys will be hosting a session with guest speakers from Unilever and Health Canada at the The 11th World Congress on Alternatives and Animal Use in the Life Science (WC11). Applications of New Approach Methods in Genotoxicity and Developmental toxicity testing Every year, large numbers of new compounds...
Toxys Newsletter July 2021
Here you can view our newsletter from July 2021 [campaign id="d6f9160929"]...
Webinar: Applications of the ToxTracker suite in early chemical safety assessment and read-across
On the 9th of June, we hosted a webinar on the applications of the ToxTracker suite in early chemical safety assessment and read-across. The webinar is now also available through the link below. During the webinar, the ToxTracker suite was introduced and we shared updates...
Latest revision of the SCCS notes of guidance for testing of cosmetic ingredients includes ToxTracker
The latest revision of the SCCS notes of guidance for testing of cosmetic ingredients was recently published and it includes ToxTracker within the toolbox for further evaluation. The mechanistic insight provided by ToxTracker into the genotoxicity of chemicals is useful as an animal-free assessment and...
ToxProfiler Webinar: a quantitative high throughput screening platform with a single-cell resolution
On the 8th of April, we hosted a webinar introducing ToxProfiler, a quantitative high throughput screening platform with a single-cell resolution. The webinar is now also available through the link below. During the webinar, it was demonstrated how ToxProfiler can generate a toxicological fingerprint for...
Imperial Brands’ latest research using ToxTracker
Imperial Brands’ scientists are the first to publish results using the assays of the ToxTracker suite for the assessment of vape e-liquids and aerosols, and it forms part of the company’s continuing research into the tobacco harm reduction potential of Next Generation Products (NGPs) such as vapes. The...
Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment
Leiden, The Netherlands and Bedford, UK, April 28, 2021 – Toxys and Unilever Safety and Environmental Assurance Centre (SEAC) have entered into an agreement to further validate and expand the ReproTracker assay. Testing for developmental toxicity according to the current international guidelines requires large numbers of...
A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods
Check out this latest publication by Proctor & Gamble, “A comparison of classical and 21st century genotoxicity tools: A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods (TGx-DDI, whole genome clustering and connectivity mapping)” published recently in Environmental...
Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay
Check out our latest publication “Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay” published recently in Mutation Research/Genetic Toxicology and Environmental Mutagenesis. In this paper published by the International Antimony Association (I2A) in collaboration with Toxys, Boreiko et...
Toxys Newsletter March 2021
Here you can view our newsletter from March 2021 [campaign id="ea2d5c8f05"]...
Toxys strengthens executive team with appointment of a CSO
Leiden, The Netherlands. Feb. 24, 2021 - Today, Toxys announces the appointment of Torben Østerlund as Chief Scientific Officer (CSO). Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative in vitro toxicity screening solutions to identify hazardous properties of compounds...
Toxys has licensed ToxProfiler technology for animal-free chemical safety testing
Leiden, The Netherlands, January 28, 2021 – Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialize and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals,...
Toxys Newsletter December 2020
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Toxys is nominated as one of the top 100 most innovative companies in the Netherlands
Toxys is nominated as one of the top 100 most innovative companies in the Netherlands by the Dutch Chamber of Commerce (KVK). The 2020 KVK Innovatie top 100 nomination recognises our mission to improve animal-free safety testing with novel in vitro assays that offer mechanistic...
Toxys is selected as one of the FD Gazelles of 2020!
Toxys is very proud to announce that we have been selected as one of the FD Gazelles of 2020! The prestigious Gazelle awards are presented by the Dutch Financial Times (Het Financieele Dagblad) to fast-growing and financially successful companies in the Netherlands over the last...
Latest publication about aneugen versus clastogen evaluation and oxidative stress-related MOA
Check out our latest publication "Aneugen versus clastogen evaluation and oxidative stress-related mode-of-action assessment of genotoxic compounds using the ToxTracker reporter assay" published recently in Toxicological Sciences. This paper highlights the extended versions of the ToxTracker assay: ToxTracker ACE and ToxTracker AO. ToxTracker ACE (Aneugen Clastogen...
We are happy to launch ToxPlot: a unique software package for ToxTracker data analysis
We are happy to launch ToxPlot: a unique software package for ToxTracker data analysis. ToxPlot is an ideal add-on for ToxTracker that further increases the value of the assay. ToxPlot allows for extensive data analysis, unbiased data interpretation, automated report generation and secure data storage....
ReproTracker Webinar: introducing our novel in vitro developmental toxicity assay
On the 3rd of September, we hosted a webinar introducing ReproTracker, our novel in vitro developmental toxicity assay. Dr. Giel Hendriks, CEO of Toxys and Sabine Hartvelt, Junior Scientist at Toxys, discussed the challenges in reproductive toxicology and why ReproTracker was developed, along with its...
Toxys appoints Susan Swarte as new non-executive Board member
Leiden, The Netherlands. July 14, 2020 - Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative in vitro toxicity screening solutions to identify carcinogenic and other hazardous properties of compounds for the pharmaceutical, chemical, cosmetics and food industry. Today, Toxys...
Webinar: A highly quantitative in vitro method for mechanistic genotoxicity screening
On the 12th of May our recorded webinar with our partners at Miltenyi Biotech, introducing our in vitro genotoxicity assay, ToxTracker®, its opportunities, advantages and challenges faced when using this assay for mechanistic toxicity testing, was released. We also highlight the potential of using reliable flow...
Toxys signs agreement with BioPartner Leiden for new laboratory
Leiden, The Netherlands. May 5, 2020 - Toxys is an innovative Dutch biotech company that develops unique animal-free laboratory tests for the safety assessment of novel medicines, chemicals, cosmetics and food. Today, Toxyssigned an agreement with BioPartner Leiden for its new laboratory facilities. In spring...
ToxTracker webinar with user applications now available!
On the 18th of March our webinar on ToxTracker, including use applications for the Fragrance and Flavour industry and Agro-Chemical industry has been held. During this webinar, our new assays, ReproTracker and TubulinTracker, were also launched. The webinar can be found at our dedicated website for all...
COVID19 Contingency Planning and Continuity of Project Delivery from Toxys
Toxys has been monitoring the global corona virus outbreak since the beginning of this year and is updating business continuity plans daily. We want to assure you that we remain dedicated to provide high quality services to our clients while also protecting the health of...
Toxys raises €2 million financing for global expansion of its unique animal-free chemical safety tests
Leiden, The Netherlands. March. 10, 2020 - Toxys is an innovative Dutch biotech company that develops unique animal-free laboratory tests for the safety assessment of novel medicines, chemicals, cosmetics and food. Today, Toxys announces a €2 million funding round from KIKK Capital, InnovationQuarter, Zeeland Investment...
Save the date: Altertox/Toxys workshop Novel in vitro methods and AOP approaches in genetic toxicology
Hands-on workshop: Novel in vitro methods and AOP approaches in genetic toxicology. By: Altertox/Toxys When: 7-8 July 2020 Where: Leiden, The Netherlands Program will be available soon, please contact us for any questions. ...
ToxTracker event and launch party at SOT 2020
You are cordially invited to join the ToxTracker event and launch party during the SOT 2020 meeting in Anaheim. During this event we will launch new assays, software and the ToxTracker Academy. We will also update you on the latest developments around ToxTracker and its...
Toxys strengthens leadership team with appointment of CBO and COO positions
Leiden, The Netherlands. Jan. 21, 2020 - Today, Toxys announces the appointment of a Chief Business Officer (CBO) and a Chief Operating Officer (COO). Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative, high-fidelity in vitro toxicity screening solutions to identify carcinogenic and other hazardous properties...
ToxTracker for regulatory applications
We are frequently asked whether ToxTracker data have ever been included in safety dossiers to the regulatory authorities. The answer is yes, but often this information is not publicly available. And in many cases we simply don’t know. But now there is an example available...
Winner of UKEMS Young Scientist Poster Award
We are very proud that our scientist Inger Brandsma won the UKEMS Young Scientist Poster Award for her poster ‘Extension of the ToxTracker reporter assay for classification of compounds with a clastogenic or aneugenic mode of action’ at BTS-UKEMS Congress 2019. ToxTracker ACE (Aneugen Clastogen Evaluation)...
Toxys Newsletter February 2019
Here you can view our newsletter from February 2019...
Charles River and Toxys Enter Agreement to offer ToxTracker® in North America
Leiden, the Netherlands, January 30, 2019 – Charles River Laboratories International, Inc (NYSE: CRL) and Toxys have entered into an agreement to offer access to ToxTracker® in North America. ToxTracker is a suite of assays that allow rapid carcinogenicity toxicity hazard identification in novel and...
Toxys appoints four new Board members to accelerate business growth
Leiden, The Netherlands. Jan. 10, 2019 - Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative, high-fidelity in vitrotoxicity screening solutions to identify carcinogenic and other hazardous properties of compounds for the pharmaceutical, chemical, cosmetics and food industry. Today, Toxys announces the...
ToxTracker ACE: direct detection of clastogens and aneugens
We now enhanced the ToxTracker assay to discriminate clastogens from aneugens, and to classify aneugens as tubulin poisons or cell cycle kinase inhibitors. This extended version of the assay is named ToxTracker ACE (Aneugen Clastogen Evaluation). ToxTracker consists of 6 different reporter cell lines to detect...
European Scientific Committee on Consumer Safety (SCCS) includes ToxTracker for MoA assessment of cosmetics ingredients
The European Scientific Committee on Consumer Safety (SCCS) recently released their updated guidance document 'Notes of Guidance for the Testing of Cosmetic Ingredients and Their Safety Evaluation'. This document contains relevant information on the different aspects of testing and safety evaluation of cosmetic substances and...
Toxys newsletter September 2018
Here you can view our newsletter from September 2018...
New Animated ToxTracker Video
ToxTracker is a stem cell-based reporter assay for detection of genotoxicity and other cancer-related chemical properties of compounds. See below to play our new video to gain a detailed understanding of the various steps of the ToxTracker protocol and how the assay is performed in our...
Greatly improved metabolising system for ToxTracker
5 July 2018 - ToxTracker is an in vitro assay that provides detailed insight into the mode-of-action of genotoxic compounds. The assay is generally performed in the absence and presence of a metabolising system. Metabolic activation of compounds is included following the industry standard by...
Collaboration with Health Canada and University of Swansea to implement quantitative analysis of ToxTracker results for human risk assessment
Toxys has started a collaboration with Health Canada and the University of Swansea to implement the Quantitative Analysis tool PROAST for ToxTracker results. There is growing interest in quantitative analysis of in vitro genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the...
ToxTracker applied for testing Cobalt nanoparticles
In collaboration with scientists at the Karolinska institute and KTH in Sweden, we recently published a paper about application of ToxTracker for genotoxicity testing of Cobalt nanoparticles. There is a growing demand for fast and reliable assays to identify nanoparticle-induced toxicity and underlying mechanisms. In the...
Toxys at SOT 2018 recap
Toxys had a busy program at the SOT 2018, next to the poster presentations and presentation at the Charles River sponsored session we organised our first ToxTracker workshop. First ToxTracker workshop Approximately 65 people have joined our first ToxTracker workshop. The workshop was started with a presentation...
ToxTracker and its application for read-across
The chemical industry and the REACH deadline REACH is the European legislation for Registration, Evaluation and Authorisation of CHemicals. It requires that each manufacturer or importer of chemicals in the European Union handling chemicals in quantities of 1 metric ton or more per year, to demonstrate...
Toxys newsletter January 2018
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First official ToxTracker workshop during SOT 2018
You are cordially invited to join the first official ToxTracker workshop during the SOT 2018 meeting in San Antonio. The workshop provides a unique opportunity to learn more about the ToxTracker reporter assay for cancer hazard assessment. We will update you on the latest developments...
Toxys and Omnigen receive MIT grant to develop Toxplot software for animal-free chemical safety testing.
4 January 2018 - Toxys and Omnigen have received a MIT grant for the development and extension of the ToxPlot software. With this grant, the ToxPlot analysis tool will be further developed to allow quantitative and hypothesis-free toxicity profiling of novel chemicals. Currently, ToxPlot is...
Toxys has been awarded Innovation Credit to further develop ReproTracker
Leiden 20 September 2017 - Today Toxys was awarded an Innovation Credit from RVO to accelerate the develop of the ReproTracker assay. ReproTracker® is a state-of-the-art in vitro reporter assay to rapidly identify compounds that disturb stem cell differentiation and early embryonic development. Testing for...
European patent for ToxTracker granted
6 July 2017 - Leiden, the Netherlands - Toxys is proud to announce that next to the US patent which already was granted, the European patent for ToxTracker, an unique genotoxicity assay, has been granted. About ToxTracker ToxTracker® assay is a state-of-the-art stem cell-based reporter assay that...
ToxTracker is featuring in the upcoming Springer Nature Webinar on Wednesday the 14th of June
Toxys presents in collaboration with Millipore, the ToxTracker assay as an innovative in vitro system for cancer hazard assessment that provides detailed insight into the mode of action of genotoxic compounds. Click here for more information ...
Toxys launches large international validation study for ToxTracker
Leiden, 1 May 2017 - Together with a consortium of leading experts in the field of genotoxicity, Toxys has started a large inter-laboratory validation study for their ToxTracker assay. With this study, Toxys aims to demonstrate the transferability, intra- and inter-laboratory reproducibility as well as...
ToxTracker included in webinar by Charles River: Avoid Program Set-Backs: Deciphering Positive Reponses
In a webinar on genetic toxicology by Charles River the ToxTracker assay was included. Via this link you can view the webinar, the information on ToxTracker starts at 38 minutes. ...
Toxys is part of organising committee for workshop: Mode of Action Approaches That Identify Genotoxic Mechanisms in Mammalian Cell Systems (May 10th 2017)
The HESI Genetic Toxicology Technical Committee (GTTC) will hold the workshop in conjunction with the Genetic Toxicology Association (GTA) annual meeting on 10 May 2017 in Newark, Delaware. The first part of the workshop is intended to establish key cellular and genetic events for defined...
Interview with Toxys CEO Giel Hendriks and cover spread in TerugbliQ – the year report from Innovation Quarter
In TerugbliQ, the year report from Innovation Quarter you can read an interview with our CEO Giel Hendriks (in Dutch), please click here for the year report and the interview...
Poster together with Concawe presented at the SOT 2017: Use of ToxTracker for Petrochemical products
The goal of this project was to investigate whether the ToxTracker assay can be applied to petroleum UVCBs as a high-content screen for mutagenicity / carcinogenicity by testing by testing twelve DMSO extracts of petroleum substances for (geno)toxic properties in the assay. Conclusions: The ToxTracker assay...
Poster together with P&G presented at the SOT 2017: use of multiparametric mode of action approaches for genetic toxicity assessment
This poster describes the investigation of several different predictive, animal-free genetic toxicology methodologies with varying degrees of complexity. The predictive capacity of these methods was compared by testing 22 chemicals that represent a mix of DNA reactive chemicals, chemicals with known, mixed or unknown modes...
Toxys mentioned as top-10 biotech in Leiden
In this article by Labiotech.eu Toxys is mentioned as one of the top-10 biotech companies in Leiden. Stroopwaffels, Krokets and Biotechs – Meet the Top 10 in Leiden! ...
ToxTracker – the better genotoxicity assay
This is the first blog in a series to come to share what we are doing at Toxys and to inspire you. Toxys provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases...
Toxys newsletter November 2016
Here you can view our newsletter for November 2016...
Toxys awarded € 50.000 by EIT Health to develop ReproTracker – an in vitro assay for reproductive toxicity
21 September 2016 - Today Toxys was awarded a €50.000 grant for a head-start project to further develop the ReproTracker. Toxys is dedicated to develop innovative in vitro toxicity assays that provide insight into the mechanisms of toxicity. Toxys' lead product ToxTracker is a genotoxicity...
ToxTracker, the future for genotoxicity screening of nanoparticles
Many of the traditional genotoxicity test methods [e.g. unscheduled DNA synthesis assay, bacterial reverse mutation (Ames) test, etc.,] for determining the DNA damaging potential of chemical and biological compounds are not suitable for the evaluation of engineered nanomaterials (ENMs), due to a variety of methodological...
Application note Millipore featuring the ToxTracker assay
Benchtop flow cytometry facilitates discrimintion between induction of DNA damage, oxidative stress and protein misfolding using a novel multicell GFP reporter assay. ...
ToxTracker suggested as part of “An integrative test strategy for cancer hazard”
A recent publication by the Dutch National Institute for Health and Environment (RIVM) reviews the current test methods for cancer hazard identification that have been adopted by the regulatory authorities and discusses the most promising alternative methods that have been developed to date. Based on...
Grand Opening new facilities Toxys
On the 26th of May Toxys organised a grand opening party. Over 50 people joined, among which were Innovation Quarter, the Leiden Bioscience Park, Biopartner and various entrepreneurs and collaborators. We are very happy with our new location and state-of-the-art equipment and look forwards to expanding...
ToxTracker assay in Gen Magazine
Check out our recent publication about the ToxTracker assay together with Millipore. The publication shows the the power of the ToxTracker reporter assay in combination with the Millipore Guava platform. ...
New Publication on how the ToxTracker assay provides mechanistic insight
Our latest publication about the development and validation of the ToxTracker assay is now available online. The paper describes the different fluorescent reporter cell lines that ar used in ToxTracker to gain insight into the mechanism of genotoxicity of compounds. The ToxTracker assay is a...
A Milestone for Toxys: Growth capital for biotech company Toxys to develop Toxicological tests
The Zeeuws Investment Fund and InnovationQuarter have invested in the biotech company Toxys, located in Leiden, The Netherlands. Toxys is a spin-off from the Leiden University Medical Centre (LUMC) and specialized in a new generation of innovative testing which quickly and reliably can identify the...
Read our latest publication about the ToxTracker assay
Just before the end of 2015, our most recent scientific description and validation of the ToxTracker technology got accepted for publication by the journal Toxicological Sciences. The publication reports on the ToxTracker assay for mechanistic genotoxicity screening. By utilising a panel of reporter genes that are...
Toxys joins IVTIP
Toxys recently joined the In Vitro Testing Industrial Platform (IVTIP). IVTIP is an informal platform that was founded in 1993 and currently comprises 42 companies from different sectors (assay developers, technology providers, chemical, pharmaceutical and cosmetics companies), with significant in vitro testing activities. Most of the...
Toxys at Eurotox 2015
Our Poster Presentations The ToxTracker reporter system is a mechanistic genotoxicity platform that discriminates clastogenic from aneugenic compounds.Giel Hendriks1, Remco Derr1, Branislav Misovic2, Bruno Morolli2, Fabienne Calléja2 and Harry Vrieling2. 1 Toxys B.V., Albinusdreef 2, 2333 ZA, Leiden, the Netherlands. g.hendriks@toxys.com 2 Department of Human Genetics, Leiden University...
Toxys receives award for best business plan
Today at the SME event from HollandBio, Toxys received the award for best business plan as part of the BioBusiness Masterclass. A jury of experts in Life Sciences acknowledged the strong technology and business opportunities at Toxys. The award is a great support for Toxys...
Toxys wins the BioBusiness Masterclass 2015
Today, Toxys won the 2015 edition of the HollandBio BioBusiness Masterclass. The Masterclass is a mini MBA for entrepreneurs in Life Sciences. I am proud of the achievements of the Toxys team. Meet us at the upcoming HollandBio SME event on the 4th of june. ...
Toxys promotion video online!
I am very proud to announce that Toxys just published a promotion video that explained our business and technology. Please view and share the video. I am looking forward to your reactions. ...
Toxys at ToxExpo during SOT 2015
Exciting! Toxys will exhibit its services and technology at the ToxExpo 2015 during the Annual meeting of the Society of Toxicology in San Diego. The SOT is the world's largest Toxicology meeting, joining leading scientists and experts from academia and industry. Meet us at booth...
New paper ToxTracker and nanoparticles
Check out our latest publication on how our stem cell-based ToxTracker reporter assay can provide insight in the mechanisms of toxicity of nanoparticles, meeting the urgent demands for better in vitro assays for toxicity testing of nanomaterials. Read abstract...
