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Toxys Newsletter September 2021
Here you can view our newsletter from September 2021 [campaign id="523f0fa92b"]...
Empirical comparison of genotoxic potency estimations: the in vitro ToxTracker versus the in vivo micronucleus assay
Check out this latest publication, “Empirical comparison of genotoxic potency estimations: the in vitro DNA-damage ToxTracker endpoints versus the in vivo micronucleus assay” published recently in Mutagenesis. In this comparative study, John Wills, Paul Rees, George Johnson and colleagues (Cambridge and Swansea Universities) used a benchmark dose (BMD)...
Toxys hosts a session at the 11th World Congress on Alternatives and Animal Use in the Life Sciences
Toxys will be hosting a session with guest speakers from Unilever and Health Canada at the The 11th World Congress on Alternatives and Animal Use in the Life Science (WC11). Applications of New Approach Methods in Genotoxicity and Developmental toxicity testing Every year, large numbers of new compounds...
Toxys Newsletter July 2021
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Webinar: Applications of the ToxTracker suite in early chemical safety assessment and read-across
On the 9th of June, we hosted a webinar on the applications of the ToxTracker suite in early chemical safety assessment and read-across. The webinar is now also available through the link below. During the webinar, the ToxTracker suite was introduced and we shared updates...
Latest revision of the SCCS notes of guidance for testing of cosmetic ingredients includes ToxTracker
The latest revision of the SCCS notes of guidance for testing of cosmetic ingredients was recently published and it includes ToxTracker within the toolbox for further evaluation. The mechanistic insight provided by ToxTracker into the genotoxicity of chemicals is useful as an animal-free assessment and...
ToxProfiler Webinar: a quantitative high throughput screening platform with a single-cell resolution
On the 8th of April, we hosted a webinar introducing ToxProfiler, a quantitative high throughput screening platform with a single-cell resolution. The webinar is now also available through the link below. During the webinar, it was demonstrated how ToxProfiler can generate a toxicological fingerprint for...
Imperial Brands’ latest research using ToxTracker
Imperial Brands’ scientists are the first to publish results using the assays of the ToxTracker suite for the assessment of vape e-liquids and aerosols, and it forms part of the company’s continuing research into the tobacco harm reduction potential of Next Generation Products (NGPs) such as vapes. The...
Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment
Leiden, The Netherlands and Bedford, UK, April 28, 2021 – Toxys and Unilever Safety and Environmental Assurance Centre (SEAC) have entered into an agreement to further validate and expand the ReproTracker assay. Testing for developmental toxicity according to the current international guidelines requires large numbers of...
A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods
Check out this latest publication by Proctor & Gamble, “A comparison of classical and 21st century genotoxicity tools: A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods (TGx-DDI, whole genome clustering and connectivity mapping)” published recently in Environmental...
Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay
Check out our latest publication “Mode of action assessment of the genotoxic properties of antimony compounds evaluated in the ToxTracker assay” published recently in Mutation Research/Genetic Toxicology and Environmental Mutagenesis. In this paper published by the International Antimony Association (I2A) in collaboration with Toxys, Boreiko et...
Toxys Newsletter March 2021
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Toxys strengthens executive team with appointment of a CSO
Leiden, The Netherlands. Feb. 24, 2021 - Today, Toxys announces the appointment of Torben Østerlund as Chief Scientific Officer (CSO). Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative in vitro toxicity screening solutions to identify hazardous properties of compounds...
Toxys has licensed ToxProfiler technology for animal-free chemical safety testing
Leiden, The Netherlands, January 28, 2021 – Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialize and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals,...
Toxys Newsletter December 2020
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Toxys is nominated as one of the top 100 most innovative companies in the Netherlands
Toxys is nominated as one of the top 100 most innovative companies in the Netherlands by the Dutch Chamber of Commerce (KVK). The 2020 KVK Innovatie top 100 nomination recognises our mission to improve animal-free safety testing with novel in vitro assays that offer mechanistic...
Toxys is selected as one of the FD Gazelles of 2020!
Toxys is very proud to announce that we have been selected as one of the FD Gazelles of 2020! The prestigious Gazelle awards are presented by the Dutch Financial Times (Het Financieele Dagblad) to fast-growing and financially successful companies in the Netherlands over the last...
Latest publication about aneugen versus clastogen evaluation and oxidative stress-related MOA
Check out our latest publication "Aneugen versus clastogen evaluation and oxidative stress-related mode-of-action assessment of genotoxic compounds using the ToxTracker reporter assay" published recently in Toxicological Sciences. This paper highlights the extended versions of the ToxTracker assay: ToxTracker ACE and ToxTracker AO. ToxTracker ACE (Aneugen Clastogen...
We are happy to launch ToxPlot: a unique software package for ToxTracker data analysis
We are happy to launch ToxPlot: a unique software package for ToxTracker data analysis. ToxPlot is an ideal add-on for ToxTracker that further increases the value of the assay. ToxPlot allows for extensive data analysis, unbiased data interpretation, automated report generation and secure data storage....
ReproTracker Webinar: introducing our novel in vitro developmental toxicity assay
On the 3rd of September, we hosted a webinar introducing ReproTracker, our novel in vitro developmental toxicity assay. Dr. Giel Hendriks, CEO of Toxys and Sabine Hartvelt, Junior Scientist at Toxys, discussed the challenges in reproductive toxicology and why ReproTracker was developed, along with its...
Toxys appoints Susan Swarte as new non-executive Board member
Leiden, The Netherlands. July 14, 2020 - Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative in vitro toxicity screening solutions to identify carcinogenic and other hazardous properties of compounds for the pharmaceutical, chemical, cosmetics and food industry. Today, Toxys...
Webinar: A highly quantitative in vitro method for mechanistic genotoxicity screening
On the 12th of May our recorded webinar with our partners at Miltenyi Biotech, introducing our in vitro genotoxicity assay, ToxTracker®, its opportunities, advantages and challenges faced when using this assay for mechanistic toxicity testing, was released. We also highlight the potential of using reliable flow...
Toxys signs agreement with BioPartner Leiden for new laboratory
Leiden, The Netherlands. May 5, 2020 - Toxys is an innovative Dutch biotech company that develops unique animal-free laboratory tests for the safety assessment of novel medicines, chemicals, cosmetics and food. Today, Toxyssigned an agreement with BioPartner Leiden for its new laboratory facilities. In spring...
ToxTracker webinar with user applications now available!
On the 18th of March our webinar on ToxTracker, including use applications for the Fragrance and Flavour industry and Agro-Chemical industry has been held. During this webinar, our new assays, ReproTracker and TubulinTracker, were also launched. The webinar can be found at our dedicated website for all...
COVID19 Contingency Planning and Continuity of Project Delivery from Toxys
Toxys has been monitoring the global corona virus outbreak since the beginning of this year and is updating business continuity plans daily. We want to assure you that we remain dedicated to provide high quality services to our clients while also protecting the health of...
Toxys raises €2 million financing for global expansion of its unique animal-free chemical safety tests
Leiden, The Netherlands. March. 10, 2020 - Toxys is an innovative Dutch biotech company that develops unique animal-free laboratory tests for the safety assessment of novel medicines, chemicals, cosmetics and food. Today, Toxys announces a €2 million funding round from KIKK Capital, InnovationQuarter, Zeeland Investment...
Save the date: Altertox/Toxys workshop Novel in vitro methods and AOP approaches in genetic toxicology
Hands-on workshop: Novel in vitro methods and AOP approaches in genetic toxicology. By: Altertox/Toxys When: 7-8 July 2020 Where: Leiden, The Netherlands Program will be available soon, please contact us for any questions. ...
ToxTracker event and launch party at SOT 2020
You are cordially invited to join the ToxTracker event and launch party during the SOT 2020 meeting in Anaheim. During this event we will launch new assays, software and the ToxTracker Academy. We will also update you on the latest developments around ToxTracker and its...
Toxys strengthens leadership team with appointment of CBO and COO positions
Leiden, The Netherlands. Jan. 21, 2020 - Today, Toxys announces the appointment of a Chief Business Officer (CBO) and a Chief Operating Officer (COO). Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative, high-fidelity in vitro toxicity screening solutions to identify carcinogenic and other hazardous properties...
ToxTracker for regulatory applications
We are frequently asked whether ToxTracker data have ever been included in safety dossiers to the regulatory authorities. The answer is yes, but often this information is not publicly available. And in many cases we simply don’t know. But now there is an example available...
Winner of UKEMS Young Scientist Poster Award
We are very proud that our scientist Inger Brandsma won the UKEMS Young Scientist Poster Award for her poster ‘Extension of the ToxTracker reporter assay for classification of compounds with a clastogenic or aneugenic mode of action’ at BTS-UKEMS Congress 2019. ToxTracker ACE (Aneugen Clastogen Evaluation)...
Toxys Newsletter February 2019
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Charles River and Toxys Enter Agreement to offer ToxTracker® in North America
Leiden, the Netherlands, January 30, 2019 – Charles River Laboratories International, Inc (NYSE: CRL) and Toxys have entered into an agreement to offer access to ToxTracker® in North America. ToxTracker is a suite of assays that allow rapid carcinogenicity toxicity hazard identification in novel and...
Toxys appoints four new Board members to accelerate business growth
Leiden, The Netherlands. Jan. 10, 2019 - Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative, high-fidelity in vitrotoxicity screening solutions to identify carcinogenic and other hazardous properties of compounds for the pharmaceutical, chemical, cosmetics and food industry. Today, Toxys announces the...
ToxTracker ACE: direct detection of clastogens and aneugens
We now enhanced the ToxTracker assay to discriminate clastogens from aneugens, and to classify aneugens as tubulin poisons or cell cycle kinase inhibitors. This extended version of the assay is named ToxTracker ACE (Aneugen Clastogen Evaluation). ToxTracker consists of 6 different reporter cell lines to detect...
European Scientific Committee on Consumer Safety (SCCS) includes ToxTracker for MoA assessment of cosmetics ingredients
The European Scientific Committee on Consumer Safety (SCCS) recently released their updated guidance document 'Notes of Guidance for the Testing of Cosmetic Ingredients and Their Safety Evaluation'. This document contains relevant information on the different aspects of testing and safety evaluation of cosmetic substances and...
Toxys newsletter September 2018
Here you can view our newsletter from September 2018...
New Animated ToxTracker Video
ToxTracker is a stem cell-based reporter assay for detection of genotoxicity and other cancer-related chemical properties of compounds. See below to play our new video to gain a detailed understanding of the various steps of the ToxTracker protocol and how the assay is performed in our...
Greatly improved metabolising system for ToxTracker
5 July 2018 - ToxTracker is an in vitro assay that provides detailed insight into the mode-of-action of genotoxic compounds. The assay is generally performed in the absence and presence of a metabolising system. Metabolic activation of compounds is included following the industry standard by...
Collaboration with Health Canada and University of Swansea to implement quantitative analysis of ToxTracker results for human risk assessment
Toxys has started a collaboration with Health Canada and the University of Swansea to implement the Quantitative Analysis tool PROAST for ToxTracker results. There is growing interest in quantitative analysis of in vitro genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the...
ToxTracker applied for testing Cobalt nanoparticles
In collaboration with scientists at the Karolinska institute and KTH in Sweden, we recently published a paper about application of ToxTracker for genotoxicity testing of Cobalt nanoparticles. There is a growing demand for fast and reliable assays to identify nanoparticle-induced toxicity and underlying mechanisms. In the...
Toxys at SOT 2018 recap
Toxys had a busy program at the SOT 2018, next to the poster presentations and presentation at the Charles River sponsored session we organised our first ToxTracker workshop. First ToxTracker workshop Approximately 65 people have joined our first ToxTracker workshop. The workshop was started with a presentation...
ToxTracker and its application for read-across
The chemical industry and the REACH deadline REACH is the European legislation for Registration, Evaluation and Authorisation of CHemicals. It requires that each manufacturer or importer of chemicals in the European Union handling chemicals in quantities of 1 metric ton or more per year, to demonstrate...
Toxys newsletter January 2018
Here you can view our newsletter from January 2018 [campaign id="5376962ead"]...
First official ToxTracker workshop during SOT 2018
You are cordially invited to join the first official ToxTracker workshop during the SOT 2018 meeting in San Antonio. The workshop provides a unique opportunity to learn more about the ToxTracker reporter assay for cancer hazard assessment. We will update you on the latest developments...
Toxys and Omnigen receive MIT grant to develop Toxplot software for animal-free chemical safety testing.
4 January 2018 - Toxys and Omnigen have received a MIT grant for the development and extension of the ToxPlot software. With this grant, the ToxPlot analysis tool will be further developed to allow quantitative and hypothesis-free toxicity profiling of novel chemicals. Currently, ToxPlot is...
Toxys has been awarded Innovation Credit to further develop ReproTracker
Leiden 20 September 2017 - Today Toxys was awarded an Innovation Credit from RVO to accelerate the develop of the ReproTracker assay. ReproTracker® is a state-of-the-art in vitro reporter assay to rapidly identify compounds that disturb stem cell differentiation and early embryonic development. Testing for...
European patent for ToxTracker granted
6 July 2017 - Leiden, the Netherlands - Toxys is proud to announce that next to the US patent which already was granted, the European patent for ToxTracker, an unique genotoxicity assay, has been granted. About ToxTracker ToxTracker® assay is a state-of-the-art stem cell-based reporter assay that...
ToxTracker is featuring in the upcoming Springer Nature Webinar on Wednesday the 14th of June
Toxys presents in collaboration with Millipore, the ToxTracker assay as an innovative in vitro system for cancer hazard assessment that provides detailed insight into the mode of action of genotoxic compounds. Click here for more information ...
Toxys launches large international validation study for ToxTracker
Leiden, 1 May 2017 - Together with a consortium of leading experts in the field of genotoxicity, Toxys has started a large inter-laboratory validation study for their ToxTracker assay. With this study, Toxys aims to demonstrate the transferability, intra- and inter-laboratory reproducibility as well as...
ToxTracker included in webinar by Charles River: Avoid Program Set-Backs: Deciphering Positive Reponses
In a webinar on genetic toxicology by Charles River the ToxTracker assay was included. Via this link you can view the webinar, the information on ToxTracker starts at 38 minutes. ...
Toxys is part of organising committee for workshop: Mode of Action Approaches That Identify Genotoxic Mechanisms in Mammalian Cell Systems (May 10th 2017)
The HESI Genetic Toxicology Technical Committee (GTTC) will hold the workshop in conjunction with the Genetic Toxicology Association (GTA) annual meeting on 10 May 2017 in Newark, Delaware. The first part of the workshop is intended to establish key cellular and genetic events for defined...
Interview with Toxys CEO Giel Hendriks and cover spread in TerugbliQ – the year report from Innovation Quarter
In TerugbliQ, the year report from Innovation Quarter you can read an interview with our CEO Giel Hendriks (in Dutch), please click here for the year report and the interview...
Poster together with Concawe presented at the SOT 2017: Use of ToxTracker for Petrochemical products
The goal of this project was to investigate whether the ToxTracker assay can be applied to petroleum UVCBs as a high-content screen for mutagenicity / carcinogenicity by testing by testing twelve DMSO extracts of petroleum substances for (geno)toxic properties in the assay. Conclusions: The ToxTracker assay...
Poster together with P&G presented at the SOT 2017: use of multiparametric mode of action approaches for genetic toxicity assessment
This poster describes the investigation of several different predictive, animal-free genetic toxicology methodologies with varying degrees of complexity. The predictive capacity of these methods was compared by testing 22 chemicals that represent a mix of DNA reactive chemicals, chemicals with known, mixed or unknown modes...
Toxys mentioned as top-10 biotech in Leiden
In this article by Labiotech.eu Toxys is mentioned as one of the top-10 biotech companies in Leiden. Stroopwaffels, Krokets and Biotechs – Meet the Top 10 in Leiden! ...
ToxTracker – the better genotoxicity assay
This is the first blog in a series to come to share what we are doing at Toxys and to inspire you. Toxys provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases...
Toxys newsletter November 2016
Here you can view our newsletter for November 2016...
Toxys awarded € 50.000 by EIT Health to develop ReproTracker – an in vitro assay for reproductive toxicity
21 September 2016 - Today Toxys was awarded a €50.000 grant for a head-start project to further develop the ReproTracker. Toxys is dedicated to develop innovative in vitro toxicity assays that provide insight into the mechanisms of toxicity. Toxys' lead product ToxTracker is a genotoxicity...
ToxTracker, the future for genotoxicity screening of nanoparticles
Many of the traditional genotoxicity test methods [e.g. unscheduled DNA synthesis assay, bacterial reverse mutation (Ames) test, etc.,] for determining the DNA damaging potential of chemical and biological compounds are not suitable for the evaluation of engineered nanomaterials (ENMs), due to a variety of methodological...
Application note Millipore featuring the ToxTracker assay
Benchtop flow cytometry facilitates discrimintion between induction of DNA damage, oxidative stress and protein misfolding using a novel multicell GFP reporter assay. ...
ToxTracker suggested as part of “An integrative test strategy for cancer hazard”
A recent publication by the Dutch National Institute for Health and Environment (RIVM) reviews the current test methods for cancer hazard identification that have been adopted by the regulatory authorities and discusses the most promising alternative methods that have been developed to date. Based on...
Grand Opening new facilities Toxys
On the 26th of May Toxys organised a grand opening party. Over 50 people joined, among which were Innovation Quarter, the Leiden Bioscience Park, Biopartner and various entrepreneurs and collaborators. We are very happy with our new location and state-of-the-art equipment and look forwards to expanding...
ToxTracker assay in Gen Magazine
Check out our recent publication about the ToxTracker assay together with Millipore. The publication shows the the power of the ToxTracker reporter assay in combination with the Millipore Guava platform. ...
New Publication on how the ToxTracker assay provides mechanistic insight
Our latest publication about the development and validation of the ToxTracker assay is now available online. The paper describes the different fluorescent reporter cell lines that ar used in ToxTracker to gain insight into the mechanism of genotoxicity of compounds. The ToxTracker assay is a...
A Milestone for Toxys: Growth capital for biotech company Toxys to develop Toxicological tests
The Zeeuws Investment Fund and InnovationQuarter have invested in the biotech company Toxys, located in Leiden, The Netherlands. Toxys is a spin-off from the Leiden University Medical Centre (LUMC) and specialized in a new generation of innovative testing which quickly and reliably can identify the...
Read our latest publication about the ToxTracker assay
Just before the end of 2015, our most recent scientific description and validation of the ToxTracker technology got accepted for publication by the journal Toxicological Sciences. The publication reports on the ToxTracker assay for mechanistic genotoxicity screening. By utilising a panel of reporter genes that are...
Toxys joins IVTIP
Toxys recently joined the In Vitro Testing Industrial Platform (IVTIP). IVTIP is an informal platform that was founded in 1993 and currently comprises 42 companies from different sectors (assay developers, technology providers, chemical, pharmaceutical and cosmetics companies), with significant in vitro testing activities. Most of the...
Toxys at Eurotox 2015
Our Poster Presentations The ToxTracker reporter system is a mechanistic genotoxicity platform that discriminates clastogenic from aneugenic compounds.Giel Hendriks1, Remco Derr1, Branislav Misovic2, Bruno Morolli2, Fabienne Calléja2 and Harry Vrieling2. 1 Toxys B.V., Albinusdreef 2, 2333 ZA, Leiden, the Netherlands. g.hendriks@toxys.com 2 Department of Human Genetics, Leiden University...
Toxys receives award for best business plan
Today at the SME event from HollandBio, Toxys received the award for best business plan as part of the BioBusiness Masterclass. A jury of experts in Life Sciences acknowledged the strong technology and business opportunities at Toxys. The award is a great support for Toxys...
Toxys wins the BioBusiness Masterclass 2015
Today, Toxys won the 2015 edition of the HollandBio BioBusiness Masterclass. The Masterclass is a mini MBA for entrepreneurs in Life Sciences. I am proud of the achievements of the Toxys team. Meet us at the upcoming HollandBio SME event on the 4th of june. ...
Toxys promotion video online!
I am very proud to announce that Toxys just published a promotion video that explained our business and technology. Please view and share the video. I am looking forward to your reactions. ...
Toxys at ToxExpo during SOT 2015
Exciting! Toxys will exhibit its services and technology at the ToxExpo 2015 during the Annual meeting of the Society of Toxicology in San Diego. The SOT is the world's largest Toxicology meeting, joining leading scientists and experts from academia and industry. Meet us at booth...
New paper ToxTracker and nanoparticles
Check out our latest publication on how our stem cell-based ToxTracker reporter assay can provide insight in the mechanisms of toxicity of nanoparticles, meeting the urgent demands for better in vitro assays for toxicity testing of nanomaterials. Read abstract...