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Pereni K

Empirical comparison of genotoxic potency estimations: the in vitro ToxTracker versus the in vivo micronucleus assay

Check out this latest publication, “Empirical comparison of genotoxic potency estimations: the in vitro DNA-damage ToxTracker endpoints versus the in vivo micronucleus assay” published recently in Mutagenesis. In this comparative study, John Wills, Paul Rees, George Johnson and colleagues (Cambridge and Swansea Universities) used a benchmark dose (BMD)...

Pereni K

Imperial Brands’ latest research using ToxTracker

Imperial Brands’ scientists are the first to publish results using the assays of the ToxTracker suite for the assessment of vape e-liquids and aerosols, and it forms part of the company’s continuing research into the tobacco harm reduction potential of Next Generation Products (NGPs) such as vapes. The...

Pereni K

Toxys strengthens executive team with appointment of a CSO

Leiden, The Netherlands. Feb. 24, 2021 - Today, Toxys announces the appointment of Torben Østerlund as Chief Scientific Officer (CSO). Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative in vitro toxicity screening solutions to identify hazardous properties of compounds...

Pereni K

Toxys is selected as one of the FD Gazelles of 2020!

Toxys is very proud to announce that we have been selected as one of the FD Gazelles of 2020! The prestigious Gazelle awards are presented by the Dutch Financial Times (Het Financieele Dagblad) to fast-growing and financially successful companies in the Netherlands over the last...

Pereni K

Latest publication about aneugen versus clastogen evaluation and oxidative stress-related MOA

Check out our latest publication "Aneugen versus clastogen evaluation and oxidative stress-related mode-of-action assessment of genotoxic compounds using the ToxTracker reporter assay" published recently in Toxicological Sciences. This paper highlights the extended versions of the ToxTracker assay: ToxTracker ACE and ToxTracker AO. ToxTracker ACE (Aneugen Clastogen...

Pereni K

Toxys appoints Susan Swarte as new non-executive Board member

Leiden, The Netherlands. July 14, 2020 - Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative in vitro toxicity screening solutions to identify carcinogenic and other hazardous properties of compounds for the pharmaceutical, chemical, cosmetics and food industry. Today, Toxys...

Paula van Rossum

Toxys signs agreement with BioPartner Leiden for new laboratory

Leiden, The Netherlands. May 5, 2020 - Toxys is an innovative Dutch biotech company that develops unique animal-free laboratory tests for the safety assessment of novel medicines, chemicals, cosmetics and food. Today, Toxyssigned an agreement with BioPartner Leiden for its new laboratory facilities. In spring...

Paula van Rossum

ToxTracker webinar with user applications now available!

On the 18th of March our webinar on ToxTracker, including use applications for the Fragrance and Flavour industry and Agro-Chemical industry has been held. During this webinar, our new assays, ReproTracker and TubulinTracker, were also launched. The webinar can be found at our dedicated website for all...

Paula van Rossum

ToxTracker event and launch party at SOT 2020

You are cordially invited to join the ToxTracker event and launch party during the SOT 2020 meeting in Anaheim. During this event we will launch new assays, software and the ToxTracker Academy. We will also update you on the latest developments around ToxTracker and its...

Paula van Rossum

Toxys strengthens leadership team with appointment of CBO and COO positions

Leiden, The Netherlands. Jan. 21, 2020 - Today, Toxys announces the appointment of a Chief Business Officer (CBO) and a Chief Operating Officer (COO). Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative, high-fidelity in vitro toxicity screening solutions to identify carcinogenic and other hazardous properties...

Paula van Rossum

ToxTracker for regulatory applications

We are frequently asked whether ToxTracker data have ever been included in safety dossiers to the regulatory authorities. The answer is yes, but often this information is not publicly available. And in many cases we simply don’t know. But now there is an example available...

Thomas Dijkmans

Winner of UKEMS Young Scientist Poster Award

We are very proud that our scientist Inger Brandsma won the UKEMS Young Scientist Poster Award for her poster ‘Extension of the ToxTracker reporter assay for classification of compounds with a clastogenic or aneugenic mode of action’ at BTS-UKEMS Congress 2019. ToxTracker ACE (Aneugen Clastogen Evaluation)...

Thomas Dijkmans

Charles River and Toxys Enter Agreement to offer ToxTracker® in North America

        Leiden, the Netherlands, January 30, 2019 – Charles River Laboratories International, Inc (NYSE: CRL) and Toxys have entered into an agreement to offer access to ToxTracker® in North America. ToxTracker is a suite of assays that allow rapid carcinogenicity toxicity hazard identification in novel and...

Thomas Dijkmans

Toxys appoints four new Board members to accelerate business growth

Leiden, The Netherlands. Jan. 10, 2019 - Toxys BV is a biotech company based in Leiden, The Netherlands, that provides innovative, high-fidelity in vitrotoxicity screening solutions to identify carcinogenic and other hazardous properties of compounds for the pharmaceutical, chemical, cosmetics and food industry. Today, Toxys announces the...

Thomas Dijkmans

ToxTracker ACE: direct detection of clastogens and aneugens

We now enhanced the ToxTracker assay to discriminate clastogens from aneugens, and to classify aneugens as tubulin poisons or cell cycle kinase inhibitors. This extended version of the assay is named ToxTracker ACE (Aneugen Clastogen Evaluation). ToxTracker consists of 6 different reporter cell lines to detect...

Thomas Dijkmans

New Animated ToxTracker Video

ToxTracker is a stem cell-based reporter assay for detection of genotoxicity and other cancer-related chemical properties of compounds. See below to play our new video to gain a detailed understanding of the various steps of the ToxTracker protocol and how the assay is performed in our...

Paula van Rossum

Greatly improved metabolising system for ToxTracker

5 July 2018 - ToxTracker is an in vitro assay that provides detailed insight into the mode-of-action of genotoxic compounds. The assay is generally performed in the absence and presence of a metabolising system. Metabolic activation of compounds is included following the industry standard by...

Paula van Rossum

ToxTracker applied for testing Cobalt nanoparticles

In collaboration with scientists at the Karolinska institute and KTH  in Sweden, we recently published a paper about application of ToxTracker for genotoxicity testing of Cobalt nanoparticles. There is a growing demand for fast and reliable assays to identify nanoparticle-induced toxicity and underlying mechanisms. In the...

Paula van Rossum

Toxys at SOT 2018 recap

Toxys had a busy program at the SOT 2018, next to the poster presentations and presentation at the Charles River sponsored session we organised our first ToxTracker workshop. First ToxTracker workshop Approximately 65 people have joined our first ToxTracker workshop. The workshop was started with a presentation...

Paula van Rossum

ToxTracker and its application for read-across

The chemical industry and the REACH deadline REACH is the European legislation for Registration, Evaluation and Authorisation of CHemicals. It requires that each manufacturer or importer of chemicals in the European Union handling chemicals in quantities of 1 metric ton or more per year, to demonstrate...

Paula van Rossum

First official ToxTracker workshop during SOT 2018

You are cordially invited to join the first official ToxTracker workshop during the SOT 2018 meeting in San Antonio. The workshop provides a unique opportunity to learn more about the ToxTracker reporter assay for cancer hazard assessment. We will update you on the latest developments...

Paula van Rossum

European patent for ToxTracker granted

6 July 2017 - Leiden, the Netherlands - Toxys is proud to announce that next to the US patent which already was granted, the European patent for ToxTracker, an unique genotoxicity assay, has been granted. About ToxTracker ToxTracker® assay is a state-of-the-art stem cell-based reporter assay that...

Paula van Rossum

Toxys launches large international validation study for ToxTracker

Leiden,  1 May 2017 - Together with a consortium of leading experts in the field of genotoxicity, Toxys has started a large inter-laboratory validation study for their ToxTracker assay. With this study, Toxys aims to demonstrate the transferability, intra- and inter-laboratory reproducibility as well as...

Paula van Rossum

Poster together with P&G presented at the SOT 2017: use of multiparametric mode of action approaches for genetic toxicity assessment

This poster describes the investigation of several different predictive, animal-free genetic toxicology methodologies with varying degrees of complexity. The predictive capacity of these methods was compared by testing 22 chemicals that represent a mix of DNA reactive chemicals, chemicals with known, mixed or unknown modes...

Paula van Rossum

Toxys mentioned as top-10 biotech in Leiden

In this article by Labiotech.eu Toxys is mentioned as one of the top-10 biotech companies in Leiden.   Stroopwaffels, Krokets and Biotechs – Meet the Top 10 in Leiden!  ...

Paula van Rossum

ToxTracker – the better genotoxicity assay

This is the first blog in a series to come to share what we are doing at Toxys and to inspire you. Toxys provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases...

Paula van Rossum

ToxTracker, the future for genotoxicity screening of nanoparticles

Many of the traditional genotoxicity test methods [e.g. unscheduled DNA synthesis assay, bacterial reverse mutation (Ames) test, etc.,] for determining the DNA damaging potential of chemical and biological compounds are not suitable for the evaluation of engineered nanomaterials (ENMs), due to a variety of methodological...

Paula van Rossum

Grand Opening new facilities Toxys

On the 26th of May Toxys organised a grand opening party. Over 50 people joined, among which were Innovation Quarter, the Leiden Bioscience Park, Biopartner and various entrepreneurs and collaborators. We are very happy with our new location and state-of-the-art equipment and look forwards to expanding...

Giel Hendriks

ToxTracker assay in Gen Magazine

Check out our recent publication about the ToxTracker assay together with Millipore. The publication shows the the power of the ToxTracker reporter assay in combination with the Millipore Guava platform. ...

Giel Hendriks

Read our latest publication about the ToxTracker assay

Just before the end of 2015, our most recent scientific description and validation of the ToxTracker technology got accepted for publication by the journal Toxicological Sciences. The publication reports on the ToxTracker assay for mechanistic genotoxicity screening. By utilising a panel of reporter genes that are...

Giel Hendriks

Toxys joins IVTIP

Toxys recently joined the In Vitro Testing Industrial Platform (IVTIP). IVTIP is an informal platform that was founded in 1993 and currently comprises 42 companies from different sectors (assay developers, technology providers, chemical, pharmaceutical and cosmetics companies), with significant in vitro testing activities. Most of the...

Giel Hendriks

Toxys at Eurotox 2015

  Our Poster Presentations The ToxTracker reporter system is a mechanistic genotoxicity platform that discriminates clastogenic from aneugenic compounds.Giel Hendriks1, Remco Derr1, Branislav Misovic2, Bruno Morolli2, Fabienne Calléja2 and Harry Vrieling2. 1 Toxys B.V., Albinusdreef 2, 2333 ZA, Leiden, the Netherlands. g.hendriks@toxys.com 2 Department of Human Genetics, Leiden University...

Giel Hendriks

Toxys receives award for best business plan

Today at the SME event from HollandBio, Toxys received the award for best business plan as part of the BioBusiness Masterclass. A jury of experts in Life Sciences acknowledged the strong technology and business opportunities at Toxys. The award is a great support for Toxys...

Giel Hendriks

Toxys wins the BioBusiness Masterclass 2015

Today, Toxys won the 2015 edition of the HollandBio BioBusiness Masterclass. The Masterclass is a mini MBA for entrepreneurs in Life Sciences. I am proud of the achievements of the Toxys team. Meet us at the upcoming HollandBio SME event on the 4th of june.  ...

Giel Hendriks

Toxys promotion video online!

I am very proud to announce that Toxys just published a promotion video that explained our business and technology. Please view and share the video. I am looking forward to your reactions.    ...

Giel Hendriks

Toxys at ToxExpo during SOT 2015

Exciting! Toxys will exhibit its services and technology at the ToxExpo 2015 during the Annual meeting of the Society of Toxicology in San Diego. The SOT is the world's largest Toxicology meeting, joining leading scientists and experts from academia and industry. Meet us at booth...

Giel Hendriks

New paper ToxTracker and nanoparticles

  Check out our latest publication on how our stem cell-based ToxTracker reporter assay can provide insight in the mechanisms of toxicity of nanoparticles, meeting the urgent demands for better in vitro assays for toxicity testing of nanomaterials. Read abstract...