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Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development.

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Paula van Rossum

Greatly improved metabolising system for ToxTracker

5 July 2018 - ToxTracker is an in vitro assay that provides detailed insight into the mode-of-action of genotoxic compounds. The assay is generally performed in the absence and presence of a metabolising system. Metabolic activation of compounds is included following the industry standard by...

Paula van Rossum

Collaboration with Health Canada and University of Swansea to implement quantitative analysis of ToxTracker results for human risk assessment

Toxys has started a collaboration with Health Canada and the University of Swansea to implement the Quantitative Analysis tool PROAST for ToxTracker results. There is growing interest in quantitative analysis of in vitro genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the...

Paula van Rossum

ToxTracker applied for testing Cobalt nanoparticles

In collaboration with scientists at the Karolinska institute and KTH  in Sweden, we recently published a paper about application of ToxTracker for genotoxicity testing of Cobalt nanoparticles. There is a growing demand for fast and reliable assays to identify nanoparticle-induced toxicity and underlying mechanisms. In the...

Paula van Rossum

Toxys at SOT 2018 recap

Toxys had a busy program at the SOT 2018, next to the poster presentations and presentation at the Charles River sponsored session we organised our first ToxTracker workshop. First ToxTracker workshop Approximately 65 people have joined our first ToxTracker workshop. The workshop was started with a presentation...

Paula van Rossum

ToxTracker and its application for read-across

The chemical industry and the REACH deadline REACH is the European legislation for Registration, Evaluation and Authorisation of CHemicals. It requires that each manufacturer or importer of chemicals in the European Union handling chemicals in quantities of 1 metric ton or more per year, to demonstrate...

Paula van Rossum

First official ToxTracker workshop during SOT 2018

You are cordially invited to join the first official ToxTracker workshop during the SOT 2018 meeting in San Antonio. The workshop provides a unique opportunity to learn more about the ToxTracker reporter assay for cancer hazard assessment. We will update you on the latest developments...

Paula van Rossum

Toxys has been awarded Innovation Credit to further develop ReproTracker

Leiden 20 September 2017 - Today Toxys was awarded an Innovation Credit from RVO to accelerate the develop of the ReproTracker assay. ReproTracker® is a state-of-the-art in vitro reporter assay to rapidly identify compounds that disturb stem cell differentiation and early embryonic development. Testing for...

Paula van Rossum

European patent for ToxTracker granted

6 July 2017 - Leiden, the Netherlands - Toxys is proud to announce that next to the US patent which already was granted, the European patent for ToxTracker, an unique genotoxicity assay, has been granted. About ToxTracker ToxTracker® assay is a state-of-the-art stem cell-based reporter assay that...

Paula van Rossum

Toxys launches large international validation study for ToxTracker

Leiden,  1 May 2017 - Together with a consortium of leading experts in the field of genotoxicity, Toxys has started a large inter-laboratory validation study for their ToxTracker assay. With this study, Toxys aims to demonstrate the transferability, intra- and inter-laboratory reproducibility as well as...

Paula van Rossum

Poster together with P&G presented at the SOT 2017: use of multiparametric mode of action approaches for genetic toxicity assessment

This poster describes the investigation of several different predictive, animal-free genetic toxicology methodologies with varying degrees of complexity. The predictive capacity of these methods was compared by testing 22 chemicals that represent a mix of DNA reactive chemicals, chemicals with known, mixed or unknown modes...