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ToxTracker ACE: direct detection of clastogens and aneugens
We now enhanced the ToxTracker assay to discriminate clastogens from aneugens, and to classify aneugens as tubulin poisons or cell cycle kinase inhibitors. This extended version of the assay is named ToxTracker ACE (Aneugen Clastogen Evaluation). ToxTracker consists of 6 different reporter cell lines to detect...
European Scientific Committee on Consumer Safety (SCCS) includes ToxTracker for MoA assessment of cosmetics ingredients
The European Scientific Committee on Consumer Safety (SCCS) recently released their updated guidance document 'Notes of Guidance for the Testing of Cosmetic Ingredients and Their Safety Evaluation'. This document contains relevant information on the different aspects of testing and safety evaluation of cosmetic substances and...
Toxys newsletter September 2018
Here you can view our newsletter from September 2018...
New Animated ToxTracker Video
ToxTracker is a stem cell-based reporter assay for detection of genotoxicity and other cancer-related chemical properties of compounds. See below to play our new video to gain a detailed understanding of the various steps of the ToxTracker protocol and how the assay is performed in our...
Greatly improved metabolising system for ToxTracker
5 July 2018 - ToxTracker is an in vitro assay that provides detailed insight into the mode-of-action of genotoxic compounds. The assay is generally performed in the absence and presence of a metabolising system. Metabolic activation of compounds is included following the industry standard by...
Collaboration with Health Canada and University of Swansea to implement quantitative analysis of ToxTracker results for human risk assessment
Toxys has started a collaboration with Health Canada and the University of Swansea to implement the Quantitative Analysis tool PROAST for ToxTracker results. There is growing interest in quantitative analysis of in vitro genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the...
ToxTracker applied for testing Cobalt nanoparticles
In collaboration with scientists at the Karolinska institute and KTH in Sweden, we recently published a paper about application of ToxTracker for genotoxicity testing of Cobalt nanoparticles. There is a growing demand for fast and reliable assays to identify nanoparticle-induced toxicity and underlying mechanisms. In the...
Toxys at SOT 2018 recap
Toxys had a busy program at the SOT 2018, next to the poster presentations and presentation at the Charles River sponsored session we organised our first ToxTracker workshop. First ToxTracker workshop Approximately 65 people have joined our first ToxTracker workshop. The workshop was started with a presentation...
ToxTracker and its application for read-across
The chemical industry and the REACH deadline REACH is the European legislation for Registration, Evaluation and Authorisation of CHemicals. It requires that each manufacturer or importer of chemicals in the European Union handling chemicals in quantities of 1 metric ton or more per year, to demonstrate...
Toxys newsletter January 2018
Here you can view our newsletter from January 2018 [campaign id="5376962ead"]...
First official ToxTracker workshop during SOT 2018
You are cordially invited to join the first official ToxTracker workshop during the SOT 2018 meeting in San Antonio. The workshop provides a unique opportunity to learn more about the ToxTracker reporter assay for cancer hazard assessment. We will update you on the latest developments...
Toxys and Omnigen receive MIT grant to develop Toxplot software for animal-free chemical safety testing.
4 January 2018 - Toxys and Omnigen have received a MIT grant for the development and extension of the ToxPlot software. With this grant, the ToxPlot analysis tool will be further developed to allow quantitative and hypothesis-free toxicity profiling of novel chemicals. Currently, ToxPlot is...
Toxys has been awarded Innovation Credit to further develop ReproTracker
Leiden 20 September 2017 - Today Toxys was awarded an Innovation Credit from RVO to accelerate the develop of the ReproTracker assay. ReproTracker® is a state-of-the-art in vitro reporter assay to rapidly identify compounds that disturb stem cell differentiation and early embryonic development. Testing for...
European patent for ToxTracker granted
6 July 2017 - Leiden, the Netherlands - Toxys is proud to announce that next to the US patent which already was granted, the European patent for ToxTracker, an unique genotoxicity assay, has been granted. About ToxTracker ToxTracker® assay is a state-of-the-art stem cell-based reporter assay that...
ToxTracker is featuring in the upcoming Springer Nature Webinar on Wednesday the 14th of June
Toxys presents in collaboration with Millipore, the ToxTracker assay as an innovative in vitro system for cancer hazard assessment that provides detailed insight into the mode of action of genotoxic compounds. Click here for more information ...
Toxys launches large international validation study for ToxTracker
Leiden, 1 May 2017 - Together with a consortium of leading experts in the field of genotoxicity, Toxys has started a large inter-laboratory validation study for their ToxTracker assay. With this study, Toxys aims to demonstrate the transferability, intra- and inter-laboratory reproducibility as well as...
ToxTracker included in webinar by Charles River: Avoid Program Set-Backs: Deciphering Positive Reponses
In a webinar on genetic toxicology by Charles River the ToxTracker assay was included. Via this link you can view the webinar, the information on ToxTracker starts at 38 minutes. ...
Toxys is part of organising committee for workshop: Mode of Action Approaches That Identify Genotoxic Mechanisms in Mammalian Cell Systems (May 10th 2017)
The HESI Genetic Toxicology Technical Committee (GTTC) will hold the workshop in conjunction with the Genetic Toxicology Association (GTA) annual meeting on 10 May 2017 in Newark, Delaware. The first part of the workshop is intended to establish key cellular and genetic events for defined...
