Toxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development.


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Publications by Toxys:

Åkerlund et al. (2018) Genotoxic and mutagenic properties of Ni and NiO nanoparticles investigated by comet assay, γ-H2AX staining, Hprt mutation assay and ToxTracker reporter cell lines. Environ Mol Mutagen 2018

Eskes C et al. (2017) Good cell culture practices & in vitro toxicology Toxicol In Vitro. 2017 Apr 24

Ates G et al. (2016). The Vitotox and ToxTracker assays: A two-test combination for quick and reliable assessment of genotoxic hazards. Mutat Res. 2016 Nov 1;810:13-21

Nelson BC et al. (2016). Emerging metrology for high-throughput nanomaterial genotoxicology. Mutagenesis. 2016 Aug 26. pii: gew037

Hendriks G, et al. (2016). The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding. Toxicol Sci. 150, 190–203.

Karlsson, H.L., et al. (2014). Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines. Part Fibre Toxicol 11, 41.

Hendriks, G., van de Water, B., Schoonen, W., and Vrieling, H. (2013). Cellular-signaling pathways unveil the carcinogenic potential of chemicals. J Appl Toxicol 33, 399–409

Hendriks, G. et al. (2012). The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals. Toxicol. Sci. 125, 285–298

Hendriks, et al. (2011). Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment. Mutat Res 709-710, 49–59.

Publications on ToxTracker:

Cappellini et al. (2018) Mechanistic insight into reactivity and (geno)toxicity of well-characterized nanoparticles of cobalt metal and oxides. Nanotoxicology. 2018 Aug 12

Mirjam Luijten, Evelyn D. Olthof, Betty C. Hakkert, Emiel Rorije, Jan- Willem van der Laan, Ruud A. Woutersen & Jan van Benthem (2016). An integrative test strategy for cancer hazard identification, Critical Reviews in Toxicology, 46:7, 615-639

Posters by Toxys

The ToxTracker as a tool for mechanism based (geno)toxic screening of nanoparticles at UKEMS 2018

Genotoxicity assessment of Antimony compounds using the ToxTracker assay presented at the SOT 2018

The ToxTracker reporter assay detects indirect genotoxicity by high levels of oxidative stress presented at the SOT 2018

Validation of the ToxTracker reporter assay for genetic toxicology assessment of petroleum products presented at the SOT 2018

Interlaboratory validation of the ToxTracker genotoxicity reporter assay presented at the SOT 2018

Genotoxicity assessment of Antimony compounds using the ToxTracker assay presented at the SOT 2018

Development of a stem cell-based reporter assay for in vitro DART assessment

Application of the ToxTracker reporter assay in a mode of action approach for genetic toxicology assessment presented at the Eurotox 2017

Use of Multiparametric Mode of action approached for Genetic Toxicity assesment: ToxTracker reporter cell lines versus gene array analysis by P&G presented at the SOT 2017

ToxTracker poster presented at the SOT 2017

Use of ToxTracker for Petrochemical products together with Concawe presented at the SOT 2017

Use of ToxTracker for Nanomaterials together with the Karolinska Institute presented at the SOT 2017

Poster presented at GTA/EMGS 2016

Poster together with Mitologics presented at Eurotox 2015