Publications by Toxys:
Ashley, A et al. (2020). A comparison of classical and 21st century genotoxicity tools: A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods (TGx-DDI, whole genome clustering and connectivity mapping). Environ Mol Mutagen. 2020;1–16.
Brandsma, I et al. (2020). Aneugen Versus Clastogen Evaluation and Oxidative Stress-Related Mode-of-Action Assessment of Genotoxic Compounds Using the ToxTracker Reporter Assay. Toxicol. Sci. 177, 202–213
McCarrick S et al. (2020) ToxTracker Reporter Cell Lines as a Tool for Mechanism-Based (geno)Toxicity Screening of Nanoparticles-Metals, Oxides and Quantum Dots. Nanomaterials (Basel). 2020 Jan 6
Sasaki et al. (2020) Application of the adverse outcome pathway framework to genotoxic modes of action. Environ Mol Mutagen. 2020 Jan
McCarrick S et al. (2019) High variability in toxicity of welding fume nanoparticles from stainless steel in lung cells and reporter cell lines: the role of particle reactivity and solubility. Nanotoxicology. 2019 Aug 16:1-17
Brown DM et al. (2019) The mechanism-based toxicity screening of particles with use in the food and nutrition sector via the ToxTracker reporter system. Toxicol In Vitro. 2019 Jul 4
Åkerlund E et al. (2018) Genotoxic and mutagenic properties of Ni and NiO nanoparticles investigated by comet assay, γ-H2AX staining, Hprt mutation assay and ToxTracker reporter cell lines. Environ Mol Mutagen 2018
Eskes C et al. (2017) Good cell culture practices & in vitro toxicology Toxicol In Vitro. 2017 Apr 24
Ates G et al. (2016). The Vitotox and ToxTracker assays: A two-test combination for quick and reliable assessment of genotoxic hazards. Mutat Res. 2016 Nov 1;810:13-21
Nelson BC et al. (2016). Emerging metrology for high-throughput nanomaterial genotoxicology. Mutagenesis. 2016 Aug 26. pii: gew037
Hendriks G et al. (2016). The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding. Toxicol Sci. 150, 190–203.
Karlsson, HL et al. (2014). Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines. Part Fibre Toxicol 11, 41.
Hendriks, G et al. (2013). Cellular-signaling pathways unveil the carcinogenic potential of chemicals. J Appl Toxicol 33, 399–409
Hendriks, G et al. (2012). The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals. Toxicol. Sci. 125, 285–298
Hendriks, G et al. (2011). Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment. Mutat Res 709-710, 49–59.
Publications on ToxTracker:
Bishop E et al (2020) An approach for the extract generation and toxicological assessment of tobacco-free ‘modern’ oral nicotine pouches. Food Chem Toxicol. 2020 Sep 14
Baltazar MT et al (2020) A next generation risk assessment case study for coumarin in cosmetic products. Toxicological Sciences. 2020 Apr 4
Cappellini et al. (2018) Mechanistic insight into reactivity and (geno)toxicity of well-characterized nanoparticles of cobalt metal and oxides. Nanotoxicology. 2018 Aug 12
Mirjam Luijten, Evelyn D. Olthof, Betty C. Hakkert, Emiel Rorije, Jan- Willem van der Laan, Ruud A. Woutersen & Jan van Benthem (2016). An integrative test strategy for cancer hazard identification, Critical Reviews in Toxicology, 46:7, 615-639
Posters by Toxys:
Combining a genotoxin-specific qPCR method with the ToxTracker to evaluate the genotoxic potential of high priority printed paper and board food contact material substances at EEMGS 2019
UKEMS Young Scientist Posters Award | Extension of the ToxTracker reporter assay for classification of compounds with a clastogenic or aneugenic mode of action at UKEMS 2019
Extension of the ToxTracker reporter assay for classification of compounds with a clastogenic or aneugenic mode of action at SOT 2019
Development of a stem cell-based reporter assay for DART assessment at SOT 2019
Adaptation of the ToxTracker reporter assay for the genetic toxicology assessment of petroleum products at SOT 2019
The ToxTracker as a tool for mechanism based (geno)toxic screening of nanoparticles at UKEMS 2018
Genotoxicity assessment of Antimony compounds using the ToxTracker assay presented at the SOT 2018
The ToxTracker reporter assay detects indirect genotoxicity by high levels of oxidative stress presented at the SOT 2018
Validation of the ToxTracker reporter assay for genetic toxicology assessment of petroleum products presented at the SOT 2018
Interlaboratory validation of the ToxTracker genotoxicity reporter assay presented at the SOT 2018
Genotoxicity assessment of Antimony compounds using the ToxTracker assay presented at the SOT 2018
Development of a stem cell-based reporter assay for in vitro DART assessment
Application of the ToxTracker reporter assay in a mode of action approach for genetic toxicology assessment presented at the Eurotox 2017
Use of Multiparametric Mode of action approached for Genetic Toxicity assesment: ToxTracker reporter cell lines versus gene array analysis by P&G presented at the SOT 2017
ToxTracker poster presented at the SOT 2017
Use of ToxTracker for Petrochemical products together with Concawe presented at the SOT 2017
Use of ToxTracker for Nanomaterials together with the Karolinska Institute presented at the SOT 2017
Poster presented at GTA/EMGS 2016
Poster together with Mitologics presented at Eurotox 2015
