Publications

Publications by Toxys:

Czekala, L., Chapman, F., Simms, L., Rudd, K., Sticken, E., Wieczorek, R., Bode, L., Pani, J., Moelijker, N., Derr, R., Brandsma, I., Hendriks, G., Stevenson, M., Walele, T. (2021). The in vitro ToxTracker and Aneugen Clastogen Evaluation extension assay as a tool in the assessment of relative genotoxic potential of e-liquids and their aerosols, Mutagenesis

Boreiko, C. J., Hendriks, G., Derr, R., Huppert, M., & Rossman, T. G. (2021). Mode of action assessment of the Genotoxic properties of antimony and its Compounds evaluated in the ToxTracker assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 865, 503333. 2021 May

Brandsma, I et al. (2020). Aneugen Versus Clastogen Evaluation and Oxidative Stress-Related Mode-of-Action Assessment of Genotoxic Compounds Using the ToxTracker Reporter Assay. Toxicol. Sci. 177, 202–213

McCarrick S et al. (2020) ToxTracker Reporter Cell Lines as a Tool for Mechanism-Based (geno)Toxicity Screening of Nanoparticles-Metals, Oxides and Quantum Dots. Nanomaterials (Basel). 2020 Jan 6

Sasaki et al. (2020) Application of the adverse outcome pathway framework to genotoxic modes of action. Environ Mol Mutagen. 2020 Jan

McCarrick S et al. (2019)  High variability in toxicity of welding fume nanoparticles from stainless steel in lung cells and reporter cell lines: the role of particle reactivity and solubility. Nanotoxicology. 2019 Aug 16:1-17

Brown DM et al. (2019) The mechanism-based toxicity screening of particles with use in the food and nutrition sector via the ToxTracker reporter system. Toxicol In Vitro. 2019 Jul 4

Åkerlund E et al. (2018) Genotoxic and mutagenic properties of Ni and NiO nanoparticles investigated by comet assay, γ-H2AX staining, Hprt mutation assay and ToxTracker reporter cell lines. Environ Mol Mutagen 2018

Eskes C et al. (2017) Good cell culture practices & in vitro toxicology Toxicol In Vitro. 2017 Apr 24

Ates G et al. (2016). The Vitotox and ToxTracker assays: A two-test combination for quick and reliable assessment of genotoxic hazards. Mutat Res. 2016 Nov 1;810:13-21

Nelson BC et al. (2016). Emerging metrology for high-throughput nanomaterial genotoxicology. Mutagenesis. 2016 Aug 26. pii: gew037

Hendriks G et al. (2016). The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding. Toxicol Sci. 150, 190–203.

Karlsson, HL et al. (2014). Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines. Part Fibre Toxicol 11, 41.

Hendriks, G et al. (2013). Cellular-signaling pathways unveil the carcinogenic potential of chemicals. J Appl Toxicol 33, 399–409

Hendriks, G et al. (2012). The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals. Toxicol. Sci. 125, 285–298

Hendriks, G et al. (2011). Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment. Mutat Res 709-710, 49–59.

Publications on ToxTracker:

Allemang, A et al. (2020). A comparison of classical and 21st century genotoxicity tools: A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods (TGx-DDI, whole genome clustering and connectivity mapping). Environ Mol Mutagen. 2020;1–16.

Bishop E et al (2020) An approach for the extract generation and toxicological assessment of tobacco-free ‘modern’ oral nicotine pouches. Food Chem Toxicol. 2020 Sep 14

Baltazar MT et al (2020) A next generation risk assessment case study for coumarin in cosmetic products. Toxicological Sciences. 2020 Apr 4

Escher, S.E. et al (2020) Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project. Arch Toxicol 93, 3643–3667 (2019).

Cappellini et al. (2018) Mechanistic insight into reactivity and (geno)toxicity of well-characterized nanoparticles of cobalt metal and oxides. Nanotoxicology. 2018 Aug 12

Mirjam Luijten, Evelyn D. Olthof, Betty C. Hakkert, Emiel Rorije, Jan- Willem van der Laan, Ruud A. Woutersen & Jan van Benthem (2016). An integrative test strategy for cancer hazard identification, Critical Reviews in Toxicology, 46:7, 615-639