About the webinar: Applications of ToxProfiler for mechanistic toxicity profiling

In general, 90% of all drug candidates fail to pass clinical trials, often due to unforeseen toxicity. Chemical safety assessment often relies on simple and general cytotoxicity endpoint measurements. To improve the predictions for the human safety of compounds, it is important to understand the underlying mechanisms of toxicity.

We developed ToxProfiler, a unique human and image-based in vitro assay that contains seven fluorescent reporter genes to visualize the major cellular stress response pathways. Based on the reporter activation patterns, ToxProfiler provides a detailed toxicological profile for each test compound and can unravel the toxicological mode of action (MoA).

During the webinar, we will showcase these case studies on how ToxProfiler:

• Can be applied in a chemical read across and minimize the use of animals: a case study with phenoxy herbicides.
• Can be applied to better understand the primary MoA of chemicals that fail to enter clinical trials: a collaboration with the Investigative Toxicology Leaders Forum (ITLF).

We will also introduce an exciting new extension of this assay, ToxProfiler MAX. This new extension can improve the assessment of mitochondrial toxicity readout: a combination of ToxProfiler with glucose/galactose medium switch assay.

In this webinar, you will learn about:

• What ToxProfiler is and how it works.
• How ToxProfiler can be applied in a chemical read across.
• How ToxProfiler can be applied to unravel the toxicological MoA of chemicals.
• The latest addition to our portfolio, ToxProfiler MAX.