MitoToxScreen: Advancing Accurate Mitochondrial Toxicity Screening
By Dr. Tamara Meijer, Study Director, Investigative Toxicology at Toxys.
This webinar is ideal for professionals involved in drug, agrochemical, chemical, and product safety assessment, particularly those interested in identifying mitochondrial liabilities earlier in the development pipeline.
Key learning points:
– Why NAMs are increasingly important for mitochondrial toxicity testing.
– What makes MitoToxScreen a unique approach.
– How MitoToxScreen was established and validated.
– How MitoToxScreen can be applied in your testing pipeline.
Tags: Agrochemicals,Chemicals,Cosmetics,Investigative toxicity,Pharmaceuticals
By Dr. Tamara Meijer, Study Director, Investigative Toxicology at Toxys. This webinar is ideal for professionals involved in drug, agrochemical, chemical, and product safety assessment, particularly those interested in identifying mitochondrial liabilities earlier in the development pipeline. Key learning points: - Why NAMs are increasingly important for mitochondrial...
Modernizing Genetic Toxicology: Strategic Applications of ToxTracker®
By Dr. Giel Hendriks (CEO and Founder of Toxys)
This webinar is designed as an industry guidance session for toxicologists and regulators who want to understand all the details and implications of the new OECD TG 446A for ToxTracker.
You’ll gain clarity on key questions such as:
- Can ToxTracker replace traditional assays?
- Where does ToxTracker fits within modern genotoxicity testing strategies?
- How can the mechanistic resolution of ToxTracker support more informed decision-making?
Tags: Genotoxicity,ToxTracker
By Dr. Giel Hendriks (CEO and Founder of Toxys) This webinar is designed as an industry guidance session for toxicologists and regulators who want to understand all the details and implications of the new OECD TG 446A for ToxTracker. You’ll gain clarity on key questions such as: ...
ToxTracker in Regulatory Submissions – User Examples in Medical Device and Chemical Industries
By Dr. Claudia Cusan, European Registered Toxicologist and Vice-President at S&C BEST Srl and Dr. Giulia Martina Sitzia, Junior Regulatory Toxicologist at KAHLBERG Consulting
During this webinar, our guest speakers share use cases for ToxTracker. The assay was applied to testing medical devices and data was submitted. Dr. Claudia Cusan share how the data was useful in decision making and filing of the compound. Then, Dr. Giulia Martina Sitzia share how ToxTracker was used in testing large molecule dyes. This class of compounds suffers from incompatibility with some of the standard genotoxicity assays. ToxTracker was useful in assessing false positives in the Ames test.
Tags: Agrochemicals,Chemicals,Genotoxicity,Pharmaceuticals,ToxTracker
By Dr. Claudia Cusan, European Registered Toxicologist and Vice-President at S&C BEST Srl and Dr. Giulia Martina Sitzia, Junior Regulatory Toxicologist at KAHLBERG Consulting During this webinar, our guest speakers share use cases for ToxTracker. The assay was applied to testing medical devices and data was...
Genotoxicity testing of N-nitrosamines using ToxTracker EMP
By Dr. Inger Brandsma, Director Genetic Toxicology at Toxys, and Dr. David Ponting, Senior Principal Scientist at Lhasa Limited
In this webinar, we introduce the Enhanced Metabolization Protocol (EMP) and its qualification and discuss effective evaluation of N-nitrosamine driven genotoxicity in mammalian cells and strategies for determining safe intake limits for nitrosamines by read-across.
Tags: Genotoxicity,ToxTracker
By Dr. Inger Brandsma, Director Genetic Toxicology at Toxys, and Dr. David Ponting, Senior Principal Scientist at Lhasa Limited In this webinar, we introduce the Enhanced Metabolization Protocol (EMP) and its qualification and discuss effective evaluation of N-nitrosamine driven genotoxicity in mammalian cells and strategies for...
Validation of ReproTracker assay for its regulatory use following ICH S5 (R3) guideline
By José Manuel Horcas Nieto, Director Developmental Toxicology
In this webinar, we present the results of our validation study using the compound list indicated in the ICH S5 (3R) guidelines (32 compounds). Following the identification of human developmental toxicants in ReproTracker, we will elaborate on the clinical relevance of the concentrations detected in the context of their respective human therapeutic Cmax values.
Tags: Developmental Toxicity,ReproTracker
By José Manuel Horcas Nieto, Director Developmental Toxicology In this webinar, we present the results of our validation study using the compound list indicated in the ICH S5 (3R) guidelines (32 compounds). Following the identification of human developmental toxicants in ReproTracker, we will elaborate on the...
ToxTracker updates – OECD draft guideline, BMD, and data visualization
By Giel Hendriks, CEO at Toxys, and Inger Brandsma, Director Genetic Toxicology
In this webinar, we share the latest updates on the ToxTracker OECD draft guideline, discuss application of BMD analysis in ToxTracker with example data, and demonstrate the novel visualization tools (PR Plots) we have developed.
Tags: Genotoxicity,ToxTracker
By Giel Hendriks, CEO at Toxys, and Inger Brandsma, Director Genetic Toxicology In this webinar, we share the latest updates on the ToxTracker OECD draft guideline, discuss application of BMD analysis in ToxTracker with example data, and demonstrate the novel visualization tools (PR Plots) we have...
Accelerating the international validation of NAMs
By Giel Hendriks, CEO at Toxys, and Jose Manuel Horcas Nieto, Director Developmental Toxicology
In this webinar, we introduce the journey of a NAM from the start of development, optimization and standardization to uptake in globally harmonized regulatory frameworks, share our experience with validation of NAMs as well as their intra- and inter-laboratory reproducibility, and discuss the adoption of NAMs internationally for decision making on the safety of medicinal products.
Tags: ReproTracker,ToxTracker
By Giel Hendriks, CEO at Toxys, and Jose Manuel Horcas Nieto, Director Developmental Toxicology In this webinar, we introduce the journey of a NAM from the start of development, optimization and standardization to uptake in globally harmonized regulatory frameworks, share our experience with validation of NAMs...
MutaTracker, a unique in vitro assay for predicting mutagenic and genotoxic mode-of-action
By Alex Maslov, Co-founder at Mutagentech and Marit Hoogenboom-Geijer, Scientist at Toxys and Study Director MutaTracker
In this webinar, we talk all about MutaTracker, the latest addition to our genetic toxicology portfolio. MutaTracker combines ToxTracker and single-molecule mutation sequencing (SMM-seq) in a single workflow. We explain how MutaTracker works, share several examples of tested chemicals, and show how to interpret the data.
Tags: Genotoxicity,MutaTracker
By Alex Maslov, Co-founder at Mutagentech and Marit Hoogenboom-Geijer, Scientist at Toxys and Study Director MutaTracker In this webinar, we talk all about MutaTracker, the latest addition to our genetic toxicology portfolio. MutaTracker combines ToxTracker and single-molecule mutation sequencing (SMM-seq) in a single workflow. We explain...
Integrating ReproTracker into DART AOPs for mechanism-based teratogenicity assessment
By Amer Jamalpoor, Chief Scientific Officer at Toxys, and Alun Myden, Principal Scientist at Lhasa
In this webinar, we illustrated how the information from adverse outcome pathway (AOP) networks complements the in vitro human-based assay ReproTracker for DART assessments and supports decision-making for chemical safety.
Tags: Developmental Toxicity,ReproTracker
By Amer Jamalpoor, Chief Scientific Officer at Toxys, and Alun Myden, Principal Scientist at Lhasa In this webinar, we illustrated how the information from adverse outcome pathway (AOP) networks complements the in vitro human-based assay ReproTracker for DART assessments and supports decision-making for chemical safety....
Consultants Symposium: Application of NAMs in chemical safety assessment
By Giel Hendriks – CEO at Toxys, Claudia Cusan – Consultant at S&C Best Srl, Sanghamitra Mishra – Senior Consultant ToxMinds
In this online symposium, we addressed a question we frequently come across in discussions with consultants: “How can NAMs be best applied in a toxicity testing strategy?” Together with 2 independent consultants we gave insights into our NAMs portfolio and actual use cases.
Tags: Agrochemicals,Chemicals,Cosmetics,Developmental Toxicity,DNA Repair-Profiler,Genotoxicity,Investigative toxicity,Pharmaceuticals,ReproTracker,ToxProfiler,ToxTracker
By Giel Hendriks - CEO at Toxys, Claudia Cusan - Consultant at S&C Best Srl, Sanghamitra Mishra - Senior Consultant ToxMinds In this online symposium, we addressed a question we frequently come across in discussions with consultants: “How can NAMs be best applied in a toxicity...
Potency ranking of PFAS using the ToxProfiler assay
By Bas ter Braak, Study Director of ToxProfiler, and Kamlesh Sodani, Principal Toxicologist, Honeywell
In this webinar, we shared a case study on the comparative analysis of different carbon chain length PFAS using ToxProfiler.
Tags: Chemicals,Investigative toxicity,ToxProfiler
By Bas ter Braak, Study Director of ToxProfiler, and Kamlesh Sodani, Principal Toxicologist, Honeywell In this webinar, we shared a case study on the comparative analysis of different carbon chain length PFAS using ToxProfiler....
Integration of ReproTracker and PBPK modeling to predict human developmental toxicity
By Sabine Hartvelt, Study Director of ReproTracker, and Marjory Moreau, Associate Director, Scitovation
In this webinar, we showed how PBPK modeling can be applied to perform quantitative in vitro to in vivo extrapolation (IVIVE) of dosimetry and evaluate whether the ReproTracker assay can predict the in vivo developmental toxicity exposure levels of drugs.
Tags: Developmental Toxicity,ReproTracker
By Sabine Hartvelt, Study Director of ReproTracker, and Marjory Moreau, Associate Director, Scitovation In this webinar, we showed how PBPK modeling can be applied to perform quantitative in vitro to in vivo extrapolation (IVIVE) of dosimetry and evaluate whether the ReproTracker assay can predict the in...
Validation of ToxTracker for Regulatory Genetox Testing Strategies
By Inger Brandsma, Study Director of ToxTracker, Dan Roberts, Director of BD & Sales, Toxys Inc. and Giel Hendriks, CEO, Toxys
In this webinar, we discussed the use of ToxTracker in genetic toxicology testing strategy and also presented findings of the inter-laboratory validation study approved by the OECD.
Tags: Genotoxicity,ToxTracker
By Inger Brandsma, Study Director of ToxTracker, Dan Roberts, Director of BD & Sales, Toxys Inc. and Giel Hendriks, CEO, Toxys In this webinar, we discussed the use of ToxTracker in genetic toxicology testing strategy and also presented findings of the inter-laboratory validation study approved by...
Applications of ToxProfiler for mechanistic toxicity profiling
By Amer Jamalpoor, Scientific Director of Toxys, and Bas her Braak, Study Director of ToxProfiler
In this webinar, we shared a few case studies for the application of ToxProfiler and we introduced an exciting new extension of this assay, ToxProfiler MAX.
Tags: Investigative toxicity,ToxProfiler
By Amer Jamalpoor, Scientific Director of Toxys, and Bas her Braak, Study Director of ToxProfiler In this webinar, we shared a few case studies for the application of ToxProfiler and we introduced an exciting new extension of this assay, ToxProfiler MAX....
Application of ReproTracker in assessing developmental toxicity according to ICH S5
By Amer Jamalpoor, Scientific Director of Toxys, and Sabine Hartvelt, Study Director of ReproTracker
In this webinar, we will show how ReproTracker fits in as an alternative assay under ICH S5 (R3) guidelines.
Tags: Developmental Toxicity,ReproTracker
By Amer Jamalpoor, Scientific Director of Toxys, and Sabine Hartvelt, Study Director of ReproTracker In this webinar, we will show how ReproTracker fits in as an alternative assay under ICH S5 (R3) guidelines....
DNA Repair-Profiler, an in vitro assay for DNA repair & genotoxic mode of action assessment
By Dr. Giel Hendriks, CEO of Toxys, and Dr. Marit Hoogenboom-Geijer, Scientist at Toxys
In this webinar, we introduced the latest assay to be added to our portfolio: DNA Repair-Profiler.
Tags: DNA Repair-Profiler,Genotoxicity
By Dr. Giel Hendriks, CEO of Toxys, and Dr. Marit Hoogenboom-Geijer, Scientist at Toxys In this webinar, we introduced the latest assay to be added to our portfolio: DNA Repair-Profiler....
Novel Safety assessment of antiviral nucleoside analogs using ToxTracker
By Dr. Giel Hendriks, CEO of Toxys, and Dr. Torben Osterlund, CSO of Toxys
In this webinar, we shared how ToxTracker can be a valuable tool to unravel the genotoxic potential of antiviral nucleoside analogues.
Tags: Genotoxicity,Pharmaceuticals,ToxTracker
By Dr. Giel Hendriks, CEO of Toxys, and Dr. Torben Osterlund, CSO of Toxys In this webinar, we shared how ToxTracker can be a valuable tool to unravel the genotoxic potential of antiviral nucleoside analogues....
ReproTracker as an in vitro alternative to animal models for developmental toxicity testing
By Dr. Giel Hendriks, CEO of Toxys, Dr. Amer Jamalpoor, Senior scientist & study director of ReproTracker, Toxys
In this webinar, the technical validation of the ReproTracker assay and the case studies with applications of the assay were presented.
Tags: Developmental Toxicity,ReproTracker
By Dr. Giel Hendriks, CEO of Toxys, Dr. Amer Jamalpoor, Senior scientist & study director of ReproTracker, Toxys In this webinar, the technical validation of the ReproTracker assay and the case studies with applications of the assay were presented....
Validation & applications of the ToxProfiler assay for mechanistic toxicity profiling
By Dr. Giel Hendriks, CEO of Toxys, Dr. Bas ter Braak, Senior scientist & study director of ToxProfiler, Toxys and Dr. Romain Grall, Advanced research engineer – Toxicogenomic, L’Oréal
In this webinar, the validation of ToxProfiler was presented and our guest speaker, Dr. Romain Grall, shared about his experience in the application of ToxProfiler for testing cosmetics ingredients.
Tags: Cosmetics,Investigative toxicity,ToxProfiler
By Dr. Giel Hendriks, CEO of Toxys, Dr. Bas ter Braak, Senior scientist & study director of ToxProfiler, Toxys and Dr. Romain Grall, Advanced research engineer – Toxicogenomic, L’Oréal In this webinar, the validation of ToxProfiler was presented and our guest speaker, Dr. Romain Grall, shared about...
Applications of the ToxTracker suite in early chemical safety assessment
By Dr. Giel Hendriks, CEO of Toxys and Dr. Naveed Honarvar, Toxicologist & Contract Manager at BASF
In this webinar, we shared updates on the ToxTracker suite and our guest speaker, Dr. Naveed Honarvar, shared his experience in using ToxTracker in the agrochemical industry.
Tags: Agrochemicals,Genotoxicity,ToxTracker
By Dr. Giel Hendriks, CEO of Toxys and Dr. Naveed Honarvar, Toxicologist & Contract Manager at BASF In this webinar, we shared updates on the ToxTracker suite and our guest speaker, Dr. Naveed Honarvar, shared his experience in using ToxTracker in the agrochemical industry....
NAMs in genotoxicity & mechanistic toxicity testing: Safety assessment of novel chemicals
By Dr. Giel Hendriks, CEO of Toxys
In this webinar hosted by (ASCCT), Dr. Giel Hendriks addressed the challenges associated with safety assessment of compounds and presented animal-free alternatives in genotoxicity and mechanistic testing offered by Toxys.
Tags: Genotoxicity,ToxTracker
By Dr. Giel Hendriks, CEO of Toxys In this webinar hosted by (ASCCT), Dr. Giel Hendriks addressed the challenges associated with safety assessment of compounds and presented animal-free alternatives in genotoxicity and mechanistic testing offered by Toxys....
ReproTracker webinar
By Dr. Giel Hendriks, CEO of Toxys and Sabine Hartvelt, Scientist at Toxys
In this webinar, ReproTracker, our in vitro developmental toxicity assay was introduced, followed by a Q&A. ReproTracker can visualise the key events during early embryonic development that allows for a reliable assessment of developmental toxicity hazards of new drugs and chemicals.
Tags: Developmental Toxicity,ReproTracker
By Dr. Giel Hendriks, CEO of Toxys and Sabine Hartvelt, Scientist at Toxys In this webinar, ReproTracker, our in vitro developmental toxicity assay was introduced, followed by a Q&A. ReproTracker can visualise the key events during early embryonic development that allows for a reliable assessment of developmental toxicity...
Applications of ToxTracker and new product launches
By Dr. Giel Hendriks, CEO of Toxys, Yax Thakkar, Genetic Toxicology Scientist at RIFM, and Dr. Raja Settivari, Leader, Genetic and Molecular Toxicology at Corteva Agriscience
In this webinar, applications of ToxTracker in the Fragrance and Flavour industry and Agro-Chemical industry were shared by guest speakers. Moreover, our new assays, ReproTracker and TubulinTracker, were also launched.
Tags: Agrochemicals,Cosmetics,Genotoxicity,ToxTracker
By Dr. Giel Hendriks, CEO of Toxys, Yax Thakkar, Genetic Toxicology Scientist at RIFM, and Dr. Raja Settivari, Leader, Genetic and Molecular Toxicology at Corteva Agriscience In this webinar, applications of ToxTracker in the Fragrance and Flavour industry and Agro-Chemical industry were shared by guest speakers....
