Latest revision of the SCCS notes of guidance for testing of cosmetic ingredients includes ToxTracker
The latest revision of the SCCS notes of guidance for testing of cosmetic ingredients was recently published and it includes ToxTracker within the toolbox for further evaluation. The mechanistic insight provided by ToxTracker into the genotoxicity of chemicals is useful as an animal-free assessment and in a Weight-of-Evidence (WOE) evaluation. These SCCS guidelines focuses more on animal alternatives and new approach methodologies (NAMs).
ToxTracker is part of the ToxTracker Suite and can contribute to a mechanism-based, animal-free, cancer hazard assessment of chemicals. ToxTracker can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens by revealing genotoxic modes-of-action and several non-genotoxic modes of action, such as oxidative stress and protein damage. ToxTracker is available as a contract service option, where the assay is performed at Toxys, or as a kit or under a license, allowing you to perform ToxTracker in your own laboratories.