Webinar: Integrating ReproTracker into DART AOP for mechanism-based teratogenicity assessment

ReproTracker

Webinar: Integrating ReproTracker into DART AOP for mechanism-based teratogenicity assessment

Webinar on ReproTracker & DART AOP framework

When: 20 June 2024, 3.00-5.00 pm CET

Register Here

Testing for developmental toxicity according to the current guidelines requires large numbers of animals. In addition to the ethical considerations and high costs of these traditional animal models, the outputs provide limited mechanistic understanding for any observed toxicity. Therefore, there is a growing demand for new approach methods (NAMs) to assess the human-relevant developmental toxicity potential of substances more accurately and more efficiently.

To help drive the evolution of developmental toxicity testing through the use of NAMs, a research collaboration was undertaken between Toxys and Lhasa Limited. Toxys developed the ReproTracker assay, a unique in vitro human-based reporter assay that can identify the teratogenic potential of new pharmaceuticals and chemicals and signify the outcome of in vivo test systems. To contextualise assay results for developmental toxicity, Lhasa Limited have developed a predictive DART adverse outcome pathway (AOP) framework which is contained within their in silico AOP solution, Kaptis.

Webinar on ReproTracker & DART AOP framework

In this webinar, we will illustrate how the information from AOP networks can complement alternative assays like ReproTracker, to enhance both industrial and regulatory confidence and reduce reliance on animal models. Through specific examples, we will demonstrate how alternative assays in combination with existing knowledge from AOP frameworks can support decision making for chemical safety through contextualised assay results and mechanistic insight.

dart aop framework with reprotracker

Would you like to learn more about this framework? Join us in our webinar!

Presentations:

Amer Jamalpoor – CSO at Toxys

Introduction to ReproTracker as a new approach methodologies (NAMs) assay that reliably classifies chemicals according to their DART profiles.

Alun Myden – Principal Scientist at Lhasa Limited

Introduction to Lhasa Limited’s predictive DART AOP framework to enhance decision making when using NAMs.

During this webinar you will learn:

  • How the ReproTracker assay works.
  • How the ReproTracker assay can be applied to assessing teratogenicity.
  • How a predictive DART AOP network can aid decision making.
  • How contextualising NAMs with a DART AOP network can provide mechanistic insights and enhance confidence in NAM results.

Webinar on ReproTracker & DART AOP framework

When: 20 June 2024, 3.00-5.00 pm CET

Register Here
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