Exploring the molecular and functional cellular response to hydrazine via transcriptomics and DNA repair mutant cell lines

Here is an interesting case study of our new DNA Repair-Profiler assay. AbbVie applied our panel of DNA repair-deficient cell lines to explore the genotoxicity of hydrazine. Hydrazine is a rodent carcinogen and is classified as a probable human carcinogen by IARC. Though hydrazine is positive in both in vitro and in vivo DNA strand break (comet) assays, hydrazine was reported to be negative in an in vitro mutation Muta Mouse lung epithelial cell (FE1) test, as well as in a regulatory-compliant, in vivo Big Blue mouse mutation test. In this article, mechanistic studies explored the cellular response to hydrazine.

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