Webinar: Integration of ReproTracker and PBPK modeling to predict human developmental toxicity
On the 11th of October, we hosted a webinar entitled “Integration of ReproTracker and PBPK modeling to predict human developmental toxicity”. During this webinar, we discussed how PBPK modeling can be applied to perform quantitative in vitro to in vivo extrapolation (IVIVE) of dosimetry and evaluate whether the ReproTracker assay can predict the in vivo developmental toxicity exposure levels of drugs.
Please click here to request the webinar from us.
ReproTracker® is a state-of-the-art human stem cell-based in vitro assay that rapidly and reliably identifies developmental toxicity hazards of new drugs and chemicals. The assay captures the key cellular events of stem cell differentiation and early embryonic development. ReproTracker is used to investigate if compounds interfere with early embryonic development and the assay can quantitatively predict their teratogenic potential. ReproTracker can be used as an early-phase developmental toxicity screening platform, an alternative for animal-free teratogenicity testing of materials, or as a tool to extrapolate animal-derived results to humans.