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Our very first hands-on ToxTracker training!
Last week, we hosted our very first hands-on ToxTracker training together with ALTERTOX on the novel in vitro methods and AOP approaches in genetic toxicology. During the workshop, the participants received a hands-on experience with ToxTracker and learnt about the latest developments in genetic toxicology. We are thankful...
Exploring the molecular and functional cellular response to hydrazine via transcriptomics and DNA repair mutant cell lines
Here is an interesting case study of our new DNA Repair-Profiler assay. AbbVie applied our panel of DNA repair-deficient cell lines to explore the genotoxicity of hydrazine. Hydrazine is a rodent carcinogen and is classified as a probable human carcinogen by IARC. Though hydrazine is...
Search for the optimal genotoxicity assay for routine testing of chemicals: Sensitivity and specificity of conventional and new test systems
In the recent publication by Mišík et al. about New Approach Methods (NAMs) for genotoxicity testing, ToxTracker was highlighted as one of the NAMs. These NAMs are advantageous in that they provide insight into the mode-of-action of genotoxic substances. The authors concluded that promising alternatives to in vivo experiments could...
Testing the RangerPro herbicide with the ToxTracker assay for a mechanistic insight into the toxicity
In a recent publication by Mesnage et al, all the pesticide ingredients in the US glyphosate-based herbicides(GBHs) RangerPro were tested for toxicity. The ToxTracker assay identified the toxicity resulting from RangerPro exposure as multifactorial, involving ER stress caused by a polyoxyethylene tallow amine, POE-15, along with oxidative stress caused by glyphosate. Please click here to read the full...
Now offering DNA Repair-Profiler, the latest addition to our genetic toxicology assays
As of today, Toxys offers DNA Repair-Profiler, the latest addition to our genetic toxicology assays. DNA Repair-Profiler consists of a unique collection of mammalian cell lines, each with a deficiency in one of the major DNA repair pathways. The cell lines are applied to assess...
Webinar: Novel safety assessment of antiviral nucleoside analogues using ToxTracker
On the 30th of June, we hosted a webinar entitled "Novel safety assessment of antiviral nucleoside analogues using ToxTracker". During this webinar we shared the background, details and conclusions for the nucleoside analogues ToxTracker case study. Please click here to request the webinar from us. About ToxTracker ToxTracker...
Toxys is interviewed by Dutch news channel about the importance of animal-testing alternatives
April 24th commemorated the World Day for Animals in Laboratories. Our CEO, Giel Hendriks, was interviewed by RTL Nieuws (Dutch national news channel) to discuss the importance of animal-testing alternatives. At Toxys, we are focused on developing assays that provide a better understanding of toxicity without...
ReproTracker Webinar: ReproTracker as an in vitro alternative to animal models for developmental toxicity testing
On the 10th of March, we hosted a webinar on ReproTracker as an in vitro alternative to animal models for developmental toxicity testing. During the webinar, the technical validation of the ReproTracker assay and the case studies with applications of the assay were presented. Please click...
Toxys opens US office and production facility to accelerate growth
Oegstgeest, The Netherlands. March 16, 2022 - Toxys BV, a Dutch biotech company that offers a broad spectrum of innovative in vitro toxicology solutions for the safety assessment of novel medicines, (agro)chemicals, cosmetics, and food ingredients, today announces the opening of a sales office in...
TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity
Check out our latest publication entitled "TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity" on the TubulinTracker assay, which studies the microtubule cytoskeleton dynamics in living cells. TubulinTracker belongs to the ToxTracker suite and can measure...
